Patents by Inventor Steven Karlen

Steven Karlen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCING PARACETAMOL FROM BIOMASS-DERIVED P-HYDROXYBENZOIC ACID AND P-HYDROXYBENZAMIDE
    Publication number: 20250059130
    Abstract: A method for producing paracetamol from renewable biological feedstocks. The method comprises isolating p-hydroxybenzoic acid (pHBA) or a mixture of pHBA and p-hydroxybenzamide (pHBAm) from biomass. One version of the method comprises converting pHBA to pHBAm, subsequently to p-aminophenol (pAmP), and subsequently to paracetamol. The yield can be increased by recycling unreacted pHBAm to feed into the amide to amine conversion step. In a second version of the method, the phenolic hydroxyl group of pHBA or pHBAm is first protected. The subsequent reactions proceed as noted, with deprotection as the last step.
    Type: Application
    Filed: August 13, 2024
    Publication date: February 20, 2025
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: John Ralph, Steven Karlen, Vitaliy Timokhin, Canan Sener
  • Synthesis of paracetamol (acetaminophen) from biomass-derived p-hydroxybenzamide
    Patent number: 10286504
    Abstract: Disclosed is a method to make N-acetyl-p-aminophenol. The method includes steps for converting biomass-derived p-hydroxybenzoates to p-hydroxybenzamide, then to p-aminophenol; and then N-acetylating the p-aminophenol.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: May 14, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John Ralph, Steven Karlen, Justin Mobley
  • SYNTHESIS OF PARACETAMOL (ACETOMINOPHEN) FROM BIOMASS-DERIVED P-HYDROXYBENZAMIDE
    Publication number: 20180258030
    Abstract: Disclosed is a method to make N-acetyl-p-aminophenol. The method includes steps for converting biomass-derived p-hydroxybenzoates to p-hydroxybenzamide, then to p-aminophenol; and then N-acetylating the p-aminophenol.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: John Ralph, Steven Karlen, Justin Mobley