Abstract: A machine learning algorithm can be trained to process signals received from a non-invasive sensor to determine an analyte. The machine learning algorithm can be a neural network trained using data obtained from the non-invasive sensor and associated analyte detection results from another sensor. The features of the data can be smoothed using a Savitzky-Golay filter, scaled, and the feature space can also be reduced, such as by Gaussian random projection. The training of the algorithm can be tested using other data obtained from the non-invasive sensor and associated analyte detection results from another sensor. Once trained, the machine learning model is used to determine levels of an analyte from signals received at a non-invasive sensor in response to transmission of a transmit signal into a subject.

Abstract: A highly accurate and safe analyte sensor that detects an analyte by transmitting and receiving sensing signals in a radio or microwave frequency range of the electromagnetic spectrum is provided. The analyte sensor has at least two antennas at least one of which operates as a transmit antenna to transmit one or more of the sensing signals and at least one of which operates as a receive antenna, and the analyte sensor meets or exceeds performance parameters for integrated continuous glucose monitoring systems as set forth in 21 C.F.R. 862.1355 (Feb. 18, 2022) and is configured to emit radiofrequency radiation less than radiofrequency radiation exposure limits as set forth in 47 C.F.R. 1.1310 (Apr. 1, 2020).

Abstract: A non-invasive analyte sensor includes one or more motion sensors and/or one or more temperature sensors. Data from the one or more motion sensors and/or one or more temperature sensors can be used to post-process the data obtained by the non-invasive analyte sensor.

Abstract: A non-invasive analyte sensor that includes at least one electromagnetic shield at least partially electromagnetically isolates an electrical component of the non-invasive analyte sensor from radio frequency interference and/or microwave frequency interference.

Abstract: A non-invasive analyte sensor that includes at least one electromagnetic shield at least partially electromagnetically isolates an electrical component of the non-invasive analyte sensor from radio frequency interference and/or microwave frequency interference.

Abstract: A method and system for transporting a fluid, gas, semi-solid, cryogen, or particulate matter, or combination thereof, between a three-dimensional structure and a substantially two-dimensional structure is disclosed. A system and method for electrically coupling a three-dimensional structure to a substantially two dimensional structure is also disclosed.

Abstract: A toothbrush has a head with tuft holes for the reception and retention of bristles therein. The tuft holes contain self-contained structures therein for the slow release of disinfectant or medication over repeated brushings. The release structure can be a capsule, a tablet, or a plurality of different timed-release microcapsules in the bottom of the tuft holes, or a coating of the agent formed on the anchor used to hold the bristles in the tuft holes.

Abstract: Dental floss and toothpicks (picks) incorporate one or more coagulants to retard and stop bleeding during flossing. In addition, or alternatively, the floss and picks incorporate tartar control, antiplaque and/or anti-bacterial agents.

Abstract: A toothbrush handle with a hollow area through which a rotatable shaft passes has a soft rubber member surrounding the shaft. A thumb-operated gear ring is secured to the rubber and the assembly is disposed in a chamber of the handle so that the ring is accessible through an opening in the outer shell of the handle. The inner chamber surface has teeth which engage the teeth on the ring and maintain it in place when the ring is pressed to displace the rubber and attached ring against the chamber teeth which prevents the shaft from being rotated when a desired angular positon of the handle and brush is achieved.