Abstract: A machine learning algorithm can be trained to process signals received from a non-invasive sensor to determine an analyte. The machine learning algorithm can be a neural network trained using data obtained from the non-invasive sensor and associated analyte detection results from another sensor. The features of the data can be smoothed using a Savitzky-Golay filter, scaled, and the feature space can also be reduced, such as by Gaussian random projection. The training of the algorithm can be tested using other data obtained from the non-invasive sensor and associated analyte detection results from another sensor. Once trained, the machine learning model is used to determine levels of an analyte from signals received at a non-invasive sensor in response to transmission of a transmit signal into a subject.

Abstract: A highly accurate and safe analyte sensor that detects an analyte by transmitting and receiving sensing signals in a radio or microwave frequency range of the electromagnetic spectrum is provided. The analyte sensor has at least two antennas at least one of which operates as a transmit antenna to transmit one or more of the sensing signals and at least one of which operates as a receive antenna, and the analyte sensor meets or exceeds performance parameters for integrated continuous glucose monitoring systems as set forth in 21 C.F.R. 862.1355 (Feb. 18, 2022) and is configured to emit radiofrequency radiation less than radiofrequency radiation exposure limits as set forth in 47 C.F.R. 1.1310 (Apr. 1, 2020).

Abstract: A non-invasive analyte sensor includes one or more motion sensors and/or one or more temperature sensors. Data from the one or more motion sensors and/or one or more temperature sensors can be used to post-process the data obtained by the non-invasive analyte sensor.

Abstract: A non-invasive analyte sensor that includes at least one electromagnetic shield at least partially electromagnetically isolates an electrical component of the non-invasive analyte sensor from radio frequency interference and/or microwave frequency interference.

Abstract: A holographic sight comprises a unitary optical component carrier having a plurality of receptacles for receiving optical components. A collimating optic abuts a surface of a first receptacle. A mirror abuts a surface of a second receptacle. A collar is positioned in a third receptacle and a laser diode is positioned within the collar. A first portion of the collar is affixed relative to a first portion of the third receptacle and a second portion of the collar is free to expand and contract relative to the third receptacle. The laser diode is affixed to the collar proximate the second portion and is free to move relative to the third receptacle with expansion and contraction of the second portion. The laser diode, the mirror, and the collimating optic are positioned relative to each other to create an optical path.

Abstract: A non-invasive analyte sensor that includes at least one electromagnetic shield at least partially electromagnetically isolates an electrical component of the non-invasive analyte sensor from radio frequency interference and/or microwave frequency interference.

Abstract: A method for operating a medical device includes activating a processor in the medical device in a low-power operating mode, measuring a first voltage level of the battery, applying at least one discharge pulse to the battery in response to the first voltage level of the battery being greater than a predetermined passivation minimum voltage threshold and less than a predetermined passivation maximum voltage threshold, measuring a second voltage level of the battery after the at least one discharge pulse, and operating the processor in the medical device in an increased-power operating mode to continue operation of the medical device only in response to the second voltage level being greater than or equal to a predetermined operating voltage threshold, the predetermined operating voltage threshold being greater than the predetermined passivation minimum voltage threshold and less than or equal to the predetermined passivation maximum voltage threshold.

Abstract: An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

Abstract: A holographic sight comprises a unitary optical component carrier having a plurality of receptacles for receiving optical components. A collimating optic abuts a surface of a first receptacle. A mirror abuts a surface of a second receptacle. A collar is positioned in a third receptacle and a laser diode is positioned within the collar. A first portion of the collar is affixed relative to a first portion of the third receptacle and a second portion of the collar is free to expand and contract relative to the third receptacle. The laser diode is affixed to the collar proximate the second portion and is free to move relative to the third receptacle with expansion and contraction of the second portion. The laser diode, the mirror, and the collimating optic are positioned relative to each other to create an optical path.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: an air-cooled condenser comprising a heat exchanger and at least one axial fan; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; a water system coupled to the air-cooled condenser, the water system comprising a water source, a water pump, and a plurality of spray nozzles positioned below the air-cooled condenser; and a control circuit coupled to the air-cooled condenser and the water system, the control circuit configured to pulse atomized water through the plurality of spray nozzles to a surface of the air-cooled condenser when a head pressure of the air-cooled condenser is higher than a predetermined value.

Abstract: A holographic sight comprises a unitary optical component carrier having a plurality of receptacles for receiving optical components. A collimating optic abuts a surface of a first receptacle. A mirror abuts a surface of a second receptacle. A collar is positioned in a third receptacle and a laser diode is positioned within the collar. A first portion of the collar is affixed relative to a first portion of the third receptacle and a second portion of the collar is free to expand and contract relative to the third receptacle. The laser diode is affixed to the collar proximate the second portion and is free to move relative to the third receptacle with expansion and contraction of the second portion. The laser diode, the mirror, and the collimating optic are positioned relative to each other to create an optical path. The collar expands and contracts in response to changes in temperature to compensate for the unitary optical component carrier expanding and contracting in response to changes in temperature.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: a plurality of air-cooled condensers, each having a heat exchanger and at least one axial fan and having a first operating state capable of condensing vaporous ammonia to form liquid ammonia; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; and a plurality of valves coupled to the plurality of air-cooled condensers and having a first configuration corresponding to the first operating state of the plurality of air-cooled condensers, and a second configuration corresponding to a second operating state of one or more of the plurality of air-cooled condensers such that the one or more of the plurality of air-cooled condensers functions as an evaporator capable of evaporating liquid ammonia to form vaporous ammonia.

Abstract: An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

Abstract: A method for operating a medical device includes activating a processor in the medical device in a low-power operating mode, measuring a first voltage level of the battery, applying at least one discharge pulse to the battery in response to the first voltage level of the battery being greater than a predetermined passivation minimum voltage threshold and less than a predetermined passivation maximum voltage threshold, measuring a second voltage level of the battery after the at least one discharge pulse, and operating the processor in the medical device in an increased-power operating mode to continue operation of the medical device only in response to the second voltage level being greater than or equal to a predetermined operating voltage threshold, the predetermined operating voltage threshold being greater than the predetermined passivation minimum voltage threshold and less than or equal to the predetermined passivation maximum voltage threshold.

Abstract: A holographic sight comprises a unitary optical component carrier having a plurality of receptacles for receiving optical components. A collimating optic abuts a surface of a first receptacle. A mirror abuts a surface of a second receptacle. A collar is positioned in a third receptacle and a laser diode is positioned within the collar. A first portion of the collar is affixed relative to a first portion of the third receptacle and a second portion of the collar is free to expand anc contract relative to the third receptacle. The laser diode is affixed to the collar proximate the second portion and is free to move relative to the third receptacle with expansion and contraction of the second portion. The laser diode, the mirror, and the collimating optic are positioned relative to each other to create an optical path. The collar expands and contracts in response to changes in temperature to compensate for the unitary optical component carrier expanding and contracting in response to changes in temperature.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: an air-cooled condenser comprising a heat exchanger and at least one axial fan; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; a water system coupled to the air-cooled condenser, the water system comprising a water source, a water pump, and a plurality of spray nozzles positioned below the air-cooled condenser; and a control circuit coupled to the air-cooled condenser and the water system, the control circuit configured to pulse atomized water through the plurality of spray nozzles to a surface of the air-cooled condenser when a head pressure of the air-cooled condenser is higher than a predetermined value.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: an air-cooled condenser comprising a heat exchanger and at least one axial fan; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; a water system coupled to the air-cooled condenser, the water system comprising a water source, a water pump, and a plurality of spray nozzles positioned below the air-cooled condenser; and a control circuit coupled to the air-cooled condenser and the water system, the control circuit configured to pulse atomized water through the plurality of spray nozzles to a surface of the air-cooled condenser when a head pressure of the air-cooled condenser is higher than a predetermined value.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: a plurality of air-cooled condensers, each having a heat exchanger and at least one axial fan and having a first operating state capable of condensing vaporous ammonia to form liquid ammonia; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; and a plurality of valves coupled to the plurality of air-cooled condensers and having a first configuration corresponding to the first operating state of the plurality of air-cooled condensers, and a second configuration corresponding to a second operating state of one or more of the plurality of air-cooled condensers such that the one or more of the plurality of air-cooled condensers functions as an evaporator capable of evaporating liquid ammonia to form vaporous ammonia.

Abstract: In some embodiments, an air-cooled ammonia refrigeration system comprises: a plurality of air-cooled condensers, each having a heat exchanger and at least one axial fan and having a first operating state capable of condensing vaporous ammonia to form liquid ammonia; an evaporator coupled to the air-cooled condenser; a subcooler positioned between the air-cooled condenser and the evaporator; a compressor coupled to the evaporator; an oil cooler coupled to the compressor; and a plurality of valves coupled to the plurality of air-cooled condensers and having a first configuration corresponding to the first operating state of the plurality of air-cooled condensers, and a second configuration corresponding to a second operating state of one or more of the plurality of air-cooled condensers such that the one or more of the plurality of air-cooled condensers functions as an evaporator capable of evaporating liquid ammonia to form vaporous ammonia.

Abstract: Systems and methods for generating a graphical interface and scheduling administrative rounds are presented. The graphical interface may present to an administrator a prioritized list of care providers based on care provider performance, care provider satisfaction, patient satisfaction, and labor data associated with the care provider. A schedule of administrative rounds to counsel the care provider may be presented to the administrator and may be based on the prioritized list, administrator and patient location, and administrator and patient schedule.