Abstract: An electrosurgical apparatus is provided. The electrosurgical apparatus includes a cannula insertable into a patient and positionable adjacent abnormal tissue. The electrosurgical apparatus includes a microwave antenna that includes a distal end having a radiating section receivable within the cannula and positionable within a patient adjacent abnormal tissue. The microwave antenna is adapted to connect to a source of electrosurgical energy for transmitting electrosurgical energy to the radiating section. A portion of the radiating section substantially encompasses a portion of the abnormal tissue and may be configured to apply pressure thereto. The microwave antenna is actuated to electrocautery treat tissue to reduce blood flow to the abnormal tissue.

Abstract: Disclosed is a light emitting diode retrofit unit including a main body housing electronics having a first end and a second end, an electrical connector at the first end of the main body and rotatably attached to the main body via a commutator, a first LED module connected at the second end of the main body via a first connector, a second LED module connected to the main body via a second connector, and a plurality of LEDs in each of the first and second LED modules.

Abstract: Disclosed is a light emitting diode bulb having a base member having a first surface and a second surface, an electrical connector at the first surface of the base member, a plurality of light emitting diode modules stacked on the second surface and along an axis line, a region defined by two radii extending from the axis and an outer periphery of the plurality of light emitting diodes modules, and a plurality of side-emitting light emitting diodes on each of the plurality of light emitting diode modules wherein the plurality of side-emitting light emitting diodes is within the region.

Abstract: Disclosed is a LED bulb having side-emitting LED modules with heatsinks therebetween which includes a base member having a first surface and a second surface, an electrical connector at the first surface of the base member, a plurality of light emitting diode modules stacked on the second surface, wherein each of the light emitting diode modules have top surface on which a plurality of light emitting diodes are positioned and a bottom surface opposite to the top surface, and a plurality of heatsinks positioned between every other one of the plurality of light emitting diode modules.

Abstract: Disclosed is a light emitting diode lamp including a plurality of LED modules having a plurality of LEDs, the plurality of LEDs being arranged in a plurality of zones, a plurality of drive modules each respectively providing pulsed direct current power to one of the plurality of zones, and LED lamp controller electrically connected to the plurality of drive modules.

Abstract: A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.

Abstract: A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath.

Abstract: The invention is a method of rotating a catheter while it is manually guided in order to increase the volume of space it passes through during a geometric mapping procedure as to provide a higher and more uniform location data point cloud density in a volumetric mapping system.

Abstract: The present invention is directed to systems, apparatus, methods and procedures for the noninvasive treatment of tissue, including treatment using microwave energy. In one embodiment of the invention a medical device and associated apparatus and procedures are used to treat dermatological conditions using, for example, microwave energy.

Abstract: The invention relates to heterologous polypeptide expression and secretion by filamentous fungi and vectors and processes for expression and secretion of such polypeptides. More particularly, the invention discloses the use of a signal sequence form an aspartic protease obtained from Trichoderma and referred to as an NSP24 signal sequence.

Abstract: Devices and methods for cooling microwave antennas are disclosed herein. The cooling systems can be used with various types of microwave antennas. One variation generally comprises a handle portion with an elongate outer jacket extending from the handle portion. A microwave antenna is positioned within the handle and outer jacket such that cooling fluid pumped into the handle comes into contact directly along a portion of the length, or a majority of the length, or the entire length of the antenna to allow for direct convective cooling. Other variations include cooling sheaths which form defined cooling channels around a portion of the antenna. Yet another variation includes passively-cooled systems which utilize expandable balloons to urge tissue away from the surface of the microwave antenna as well as cooling sheaths which are cooled through endothermic chemical reactions. Furthermore, the microwave antennas themselves can have cooling lumens integrated directly therethrough.

Abstract: High-strength microwave antenna assemblies and methods of use are described herein. The microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. Proximal and distal radiating portions of the antenna assembly are separated by a junction member. A reinforcing member is disposed within the junction member to increase structural rigidity.

Abstract: This invention is an improved tissue-localizing device with an electrically energized locator element for fixedly yet removal marking a volume of tissue containing a suspect region for excision. The electrical energizing of the locator element facilitates the penetration of the locator element in to subject's tissue and minimizes resistance due to dense or calcified tissues. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Delivery of electric cut-rent may be achieved through monopolar or bipolar electronic configuration depending on design needs. Various energy sources, e.g, radio frequency, microwave or ultrasound, may be implemented in this energized tissue-localizing device.

Abstract: The method disclosed herein, relates generally to introducing molecules such as biomolecules (e.g., nucleic acids) into a filamentous fungus. More specifically, the methods disclosed herein relate to introducing one or more nucleic acids into a filamentous fungus.

Abstract: A light guide plate having a top surface through which light is emitted, a bottom surface opposite to the top surface and a side surface between the top and bottom surfaces, a bottom reflector on the bottom surface for reflecting light at the bottom surface back into the light guide plate, light emitting diodes at the side surface and a side reflector on the side surface for reflecting light at the side surface back into the light guide plate, wherein the side reflector on the side surface has an opening corresponding to at least one of the light emitting diodes

Abstract: A light emitting diode bulb includes: a base having a screw-in type electrical connector at a first end of the base; a power converter in the base for converting alternating current voltage into direct current voltage; a plurality of light emitting diode modules stacked on the base, wherein each of the light emitting diode modules have a plurality of side-emitting light emitting diodes; and a cover surrounding the plurality of light emitting diode modules stacked on the base.

Abstract: The present invention is directed to systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy. In one embodiment of the invention a medical device and associated apparatus and procedures are used to treat dermatological conditions using microwave energy.

Abstract: High-strength microwave antenna assemblies and methods of use are described herein. The microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. Proximal and distal radiating portions of the antenna assembly are separated by a junction member. A reinforcing member is disposed within the junction member to increase structural rigidity.

Abstract: Systems, methods and devices for creating an effect using microwave energy to specified tissue are disclosed herein. A system for the application of microwave energy to a tissue can include, in some embodiments, a signal generator adapted to generate a microwave signal having predetermined characteristics, an applicator connected to the generator and adapted to apply microwave energy to tissue, the applicator comprising one or more microwave antennas and a tissue interface, a vacuum source connected to the tissue interface, a cooling source connected to said tissue interface, and a controller adapted to control the signal generator, the vacuum source, and the coolant source. The tissue may include a first layer and a second layer, the second layer below the first layer, and the controller is configured such that the system delivers energy such that a peak power loss density profile is created in the second layer.

Abstract: A lighting device comprising: a light emitting diode lighting panel having first and second opposing surfaces; light emitting diodes at a periphery of light emitting diode lighting panel for emitting light through the first surface; a reflective surface at the second surface of the light emitting diode lighting panel; and a power supply unit connected to the light emitting diode panel, the power supply having first and second ends, and electrical circuitry for converting alternating current to direct current between the first and second ends, wherein the first end is for insertion into the a socket.