Abstract: 1,2,4-Tiazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: A filter element removably located in a housing having a central valve structure. The element has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion. The valve actuating portion includes a plurality of thin, flat keys spaced around the annular base and projecting radially inward from the cylindrical portion and axially outward from the base. The keys engage the valve structure in the housing when the element is installed, and open up a flow passage through the housing.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Abstract: A filter assembly includes housing enclosing a replaceable filter element. A support core is provided in the housing, and includes an extension and locking assembly. The element includes a ring of filtration media with a pair of end caps. The first end cap includes a central opening to receive the support core. The extension and locking assembly prevents the cover of the housing from being attached to the housing body without a proper filter element installed. The extension and locking assembly includes a bypass member and a locking member, which are in locking engagement when an element is absent in the housing. The second end cap includes internal protrusions which engage the locking member when the filter element is installed to disengage the bypass member from the support core, and allow the element to be inserted and the cover to be installed.

Abstract: The present invention provides a wax motor actuated valve assembly for controlling the flow of coolant to a heater core or cores until the coolant reaches a predetermined operating temperature. The wax motor actuated valve has particular application to vehicle cabin heating systems comprising front and rear heat exchangers (cores) over which air can pass for heating front and rear portions of the cabin, respectively. Initially, flow to the rear heat exchanger is shut off until the temperature of the coolant reaches a predetermined elevated temperature, whereby initial coolant flow is directed to the front heat exchanger for more rapid heating of the forward portion of the vehicle cabin. After the predetermined elevated temperature has been reached, the wax motor valve assembly is actuated to supply coolant to the rear heat exchanger for heating the rear portion of the vehicle cabin.

Abstract: The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.

Abstract: A filter assembly includes housing enclosing a replaceable filter element. A support core is provided in the housing, and includes an extension and locking assembly. The element includes a ring of filtration media with a pair of end caps. The first end cap includes a central opening to receive the support core. The extension and locking assembly prevents the cover of the housing from being attached to the housing body without a proper filter element installed. The extension and locking assembly includes a bypass member and a locking member, which are in locking engagement when an element is absent in the housing. The second end cap includes internal protrusions which engage the locking member when the filter element is installed to disengage the bypass member from the support core, and allow the element to be inserted and the cover to be installed.

Abstract: A filter assembly includes housing enclosing a replaceable filter element. A support core is provided in the housing, and includes an extension and locking assembly. The element includes a ring of filtration media with a pair of end caps. The first end cap includes a central opening to receive the support core. The extension and locking assembly prevents the cover of the housing from being attached to the housing body without a proper filter element installed. The extension and locking assembly includes a bypass member and a locking member, which are in locking engagement when an element is absent in the housing. The second end cap includes internal protrusions which engage the locking member when the filter element is installed to disengage the bypass member from the support core, and allow the element to be inserted and the cover to be installed.

Abstract: A filter element removably located in a housing having a central valve structure. The element has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion. The valve actuating portion includes a plurality of thin, flat keys spaced around the annular base and projecting radially inward from the cylindrical portion and axially outward from the base. The keys engage the valve structure in the housing when the element is installed, and open up a flow passage through the housing.

Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.

Abstract: A fuel filter includes mating housing portions defining an interior cavity. A pipe in the housing includes a central flow passage with an opening along the length of the pipe, and an exterior groove. A latch device with discrete fingers closely surrounds the pipe and is engageable with the groove to prevent the latch device (68) from moving axially along the pipe. The latch device has an annular sleeve, radially-outwardly spaced from the fingers. A moveable valve device surrounds the pipe and has a valve sleeve normally covering the opening in the pipe. An annular base on the sleeve includes radially projecting tabs defining a plurality of slots. A filter element is removeably located in the housing and has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion.

Abstract: A door comprising two metal panels and an internal core structure. The panels have their edges formed around a perimeter sub-frame of channel construction, the base of the channel being internally adjacent the respective edge of the door. Opposing edges of the panels are seam welded together to provide a flush finish, and the base of the channel is apertured to act as a heat sink and to allow weld gas to escape.