Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongate lengthwise-continuous lesion in tissue comprises an elongate shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section is controllably deployed to match the contour of an anatomical region to be treated. In embodiments the distal treatment section includes a superelastic material and can assume a plurality of different shapes based on the distance ejected from an outer sleeve member. When the catheter is activated, heat is transferred between a target tissue and the distal treatment section of the catheter thereby creating the elongate lengthwise-continuous lesion in the tissue.

Abstract: A cryoablation catheter for creating at least one lesion in tissue, the catheter having an elongate shaft with an intermediate section and a distal tip movable relative to the intermediate section. The catheter also includes at least one elongate control member extending along the intermediate section and secured to the distal tip where the elongate control member is movable relative to the intermediate section for causing movement of the distal tip relative to the intermediate section and at least one energy delivery member extending along the intermediate section to the distal tip where the at least one energy delivery member includes a linear first configuration and an elliptical second configuration. Manipulation of the control member adjusts the shape of the at least one energy delivery member.

Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongate lengthwise-continuous lesion in tissue comprises an elongate shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section is controllably deployed to match the contour of an anatomical region to be treated. In embodiments the distal treatment section includes a superelastic material and can assume a plurality of different shapes based on the distance ejected from an outer sleeve member. When the catheter is activated, heat is transferred between a target tissue and the distal treatment section of the catheter thereby creating the elongate lengthwise-continuous lesion in the tissue.

Abstract: A small gauge pulsed electric field/aspirator probe. The probe has a generally cylindrical cannula with a generally smooth distal end. A port is located near a distal end of the cannula on a side of the cannula. A pair of electrodes is located at the port. An electric pulse generator is coupled to the pair of electrodes. A distance between the distal end of the cannula and the port is approximately equal to the distance between a back wall of Schlemm's canal and a trabecular meshwork in a human eye. The electric pulse generator applies a pulsed electric field to the pair of electrodes sufficient to dissociate protein bonds that hold the trabecular meshwork together.

Abstract: A catheter usable for cryogenic ablation of tissues is described. The catheter has a deflectable segment with a reduced diameter and a tip portion with a diameter greater than the reduced diameter. A resilient element allows for bending of the deflectable segment preferentially in one plane, and an actuator is used to control the bending of the deflectable segment.

Abstract: A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the sheath and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip is biased against the cold tip on the probe by a biasing element in the sheath assembly, to promote heat transfer.