Abstract: Methods and compositions for the treatment of fibrosing diseases are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of CCL21 either alone or in combination with CCL19 will be effective in reducing the presence of fibrotic lesions and ameliorating the symptoms of fibrosing disorders.

Abstract: A method, apparatus, and computer program product are disclosed for reducing the number of unnecessarily broadcast local requests to reduce the latency to access data from remote nodes in an SMP computer system. A shared invalid cache coherency protocol state is defined that predicts whether a memory read request to read data in a shared cache line can be satisfied within a local node. When a cache line is in the shared invalid state, a valid copy of the data is predicted to be located in the local node. When a cache line is in the invalid state and not in the shared invalid state, a valid copy of the data is predicted to be located in one of the remote nodes. Memory read requests to read data in a cache line that is not currently in the shared invalid state are broadcast first to remote nodes.

Abstract: A method, apparatus, and computer program product are disclosed for reducing the number of unnecessarily broadcast remote requests to reduce the latency to access data from local nodes and to reduce global traffic in an SMP computer system. A modified invalid cache coherency protocol state is defined that predicts whether a memory access request to read or write data in a cache line can be satisfied within a local node. When a cache line is in the modified invalid state, the only valid copies of the data are predicted to be located in the local node. When a cache line is in the invalid state and not in the modified invalid state, a valid copy of the data is predicted to be located in one of the remote nodes. Memory access requests to read exclusive or write data in a cache line that is not currently in the modified invalid state are broadcast first to all nodes.

Abstract: A cache coherent data processing system includes at least first and second coherency domains each including at least one processing unit. The first coherency domain includes a first cache memory, and the second coherency domain includes a coherent second cache memory. The first cache memory within the first coherency domain of the data processing system holds a memory block in a storage location associated with an address tag and a coherency state field. The coherency state field is set to a state that indicates that the address tag is valid, that the storage location does not contain valid data, and that the memory block is likely cached only within the first coherency domain.

Abstract: We present a “directory extension” (hereinafter “DX”) to aid in prefetching between proximate levels in a cache hierarchy. The DX may maintain (1) a list of pages which contains recently ejected lines from a given level in the cache hierarchy, and (2) for each page in this list, the identity of a set of ejected lines, provided these lines are prefetchable from, for example, the next level of the cache hierarchy. Given a cache fault to a line within a page in this list, other lines from this page may then be prefetched without the substantial overhead to directory lookup which would otherwise be required.

Abstract: The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2 responses to TH1 responses by administering IL-13 receptor-targeted immunotoxins to the respiratory tract.