Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: A voltage monitoring and indicating circuit for producing an output pulse at an output terminal in response to the loss of a positive dc input voltage at an input terminal. A capacitor is charged during the presence of an input voltage at the input terminal, and a transistor coupled to the capacitor and to the output terminal operates in a non-conducting state so that no voltage pulse is produced by the transistor at the output terminal. In the event of a subsequent loss of the input voltage, the capacitor discharges into the transistor and causes the transistor to operate in a conducting state and a discharge path to be provided through the transistor for the capacitor. As the discharge takes place, an exponentially-decaying pulse is produced by the transistor at the output terminal.

Abstract: A noise-immune master timing generator operable to produce timing signals synchronized with external reference signals and to maintain phase synchronization even in a noise environment. First and second gate signals of different time duration are derived from a counter chain of the master timing generator and examined with respect to the time of occurrence of an external reference signal.If the reference signal is within the first gate signal, as occurs during normal, noise-free conditions, there is no adjustment of the counting chain to resynchronize the counting chain to the reference signal.