Patents by Inventor Steven L. Bennett

Steven L. Bennett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240239788
    Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
    Type: Application
    Filed: April 15, 2022
    Publication date: July 18, 2024
    Inventors: David L. Sloman, Gianni Chessari, Patrick Schöpf, Steven Howard, Yuichi Kawai, Kazuaki Shibata, Hiroki Asakura, Takao Uno, Takeshi Sagara, Masayuki Nakamura, Yu Kobayakawa, David Jonathan Bennett, Indu Bharathan, Thomas H. Graham, Yongxin Han, Zahid Hussain, Xiaoshen Ma, Mihir Mandal, Ryan D. Otte, Anandan Palani, Uma Swaminathan, Mycah Uehling, Yingchun Ye, Ryan Chau, Alec H. Christian, Symon Gathiaka, Timothy J. Henderson, Elisabeth T. Hennessy, Andrew J. Hoover, Shuhei Kawamura, Igri Kolaj, Thomas W. Lyons, Matthew J. Mitcheltree, Aaron Sather
  • Publication number: 20210268141
    Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
    Type: Application
    Filed: February 12, 2021
    Publication date: September 2, 2021
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
  • Patent number: 10940231
    Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: March 9, 2021
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
  • Patent number: 10722224
    Abstract: A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member. The wound closure device may further include a foam structure. The wound closure device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: July 28, 2020
    Assignee: Covidien LP
    Inventors: Joshua Stopek, Steven L. Bennett, Timothy Sargeant
  • Publication number: 20190357935
    Abstract: A surgical device includes a handle, an elongated tube extending distally from the handle, and a suction tip at a distal end portion of the elongated tube. The suction tip has a cavity formed therein. A cutting blade is positioned at least partially within the cavity and rotatable across the cavity to sever tissue, the cavity dimensioned to receive the severed tissue for removal from a patient's body.
    Type: Application
    Filed: August 9, 2019
    Publication date: November 28, 2019
    Inventors: Danyel J. Racenet, Timothy N. Wells, Steven L. Bennett, Amin Elachchabi, Michael J. Bettuchi, Miles William Noel Hember
  • Patent number: 10420578
    Abstract: A surgical device includes a handle, an elongated tube extending distally from the handle, and a suction tip at a distal end portion of the elongated tube. The suction tip has a cavity formed therein. A cutting blade is positioned at least partially within the cavity and rotatable across the cavity to sever tissue, the cavity dimensioned to receive the severed tissue for removal from a patient's body.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: September 24, 2019
    Assignee: Covidien LP
    Inventors: Danyel J. Racenet, Timothy N. Wells, Steven L. Bennett, Amin Elachchabi, Michael J. Bettuchi, Miles William Noel Hember
  • Patent number: 9931116
    Abstract: A tissue buttress is provided on at least a first and second jaw of a surgical stapling apparatus. The tissue buttress comprises an electrophilic component and a nucleophilic component. At least a portion of the tissue buttress may be disposed within either or both of the staple pockets and staple forming pockets, securing the tissue buttress to at least one of the staple jaws.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: April 3, 2018
    Assignee: COVIDIEN LP
    Inventors: Danyel Racenet, Steven L. Bennett, Erik Carlson, Kenneth H. Whitfield, Gregg Krehel
  • Publication number: 20170216487
    Abstract: Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.
    Type: Application
    Filed: April 10, 2017
    Publication date: August 3, 2017
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett
  • Publication number: 20170172600
    Abstract: A surgical device includes a handle, an elongated tube extending distally from the handle, and a suction tip at a distal end portion of the elongated tube. The suction tip has a cavity formed therein. A cutting blade is positioned at least partially within the cavity and rotatable across the cavity to sever tissue, the cavity dimensioned to receive the severed tissue for removal from a patient's body.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 22, 2017
    Inventors: Danyel J. Racenet, Timothy N. Wells, Steven L. Bennett, Amin Elachchabi, Michael J. Bettuchi, Miles William Noel Hember
  • Patent number: 9622765
    Abstract: A surgical device comprising a handle, an elongated tube extending distally from the handle, and a suction tip at a distal end portion of the elongated tube. The suction tip has a cavity formed therein. A cutting blade is positioned at least partially within the cavity and rotatable across the cavity to sever tissue, the cavity dimensioned to receive the severed tissue for removal from a patient's body.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: April 18, 2017
    Assignee: Covidien LP
    Inventors: Danyel J. Racenet, Timothy N. Wells, Steven L. Bennett, Amin Elachchabi, Michael J. Bettuchi, Miles William Noel Hember
  • Publication number: 20160310633
    Abstract: The present disclosure relates to compositions suitable for use as medical devices and/or coatings thereon. In embodiments, the compositions may be used to adhere and/or seal tissue. In other embodiments, coatings may be used to at least temporarily affix a medical device to tissue. The coatings may affix a medical device to tissue without the need for additional fixation devices or, in embodiments, may be used with other fixation devices to affix a medical device to tissue.
    Type: Application
    Filed: March 17, 2016
    Publication date: October 27, 2016
    Inventors: Lauren Vernlund, Walter Skalla, Nathaniel Mast, Steven L. Bennett
  • Publication number: 20160135797
    Abstract: A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member. The wound closure device may further include a foam structure. The wound closure device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 19, 2016
    Inventors: Joshua Stopek, Steven L. Bennett, Timothy Sargeant
  • Patent number: 9271706
    Abstract: A wound closure device for repairing perforations and tissue wall defects is disclosed herein. The wound closure device has a barbed elongate body and a plug member. The wound closure device may further include a foam structure. The wound closure device may also include an inner member which may be a tissue scaffold. A method for closing tissue is also disclosed.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: March 1, 2016
    Assignee: Covidien LP
    Inventors: Joshua Stopek, Steven L. Bennett, Timothy Sargeant
  • Patent number: 8932618
    Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: January 13, 2015
    Assignee: Confluent Surgical, Inc.
    Inventors: Phillip D. Blaskovich, Rachit Ohri, Steven L. Bennett
  • Publication number: 20140341836
    Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
    Type: Application
    Filed: July 9, 2014
    Publication date: November 20, 2014
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
  • Patent number: 8889889
    Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: November 18, 2014
    Assignee: Confluent Surgical, Inc.
    Inventors: Rachit Ohri, Phillip Blaskovich, Joshua Kennedy, Steven L. Bennett, Arthur Driscoll
  • Patent number: 8795709
    Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: August 5, 2014
    Assignee: Incept LLC
    Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
  • Publication number: 20140209658
    Abstract: A surgical stapling apparatus includes a cartridge assembly, an anvil assembly, a surgical buttress, and a low molecular weight bioabsorbable adhesive. The cartridge assembly includes a plurality of staples and a tissue contacting surface defining staple retaining slots. The anvil assembly includes a tissue contacting surface defining staple pockets for forming staples expelled from the staple retaining slots of the cartridge assembly. The surgical buttress is disposed on at least one of the tissue contacting surfaces of the cartridge assembly and the anvil assembly. The low molecular weight bioabsorbable adhesive releasably retains the surgical buttress on the at least one of the tissue contacting surfaces of the cartridge assembly and the anvil assembly.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 31, 2014
    Applicant: Covidien LP
    Inventors: Walter Skalla, Steven L. Bennett, Danyel Racenet
  • Publication number: 20130296833
    Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
    Type: Application
    Filed: July 11, 2013
    Publication date: November 7, 2013
    Inventors: PHILLIP D. BLASKOVICH, RACHIT OHRI, STEVEN L. BENNETT
  • Patent number: 8512749
    Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: August 20, 2013
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, Peter G. Edelman, Steven L. Bennett