Abstract: Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced.

Abstract: Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced.

Abstract: The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

Abstract: The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for treating and inhibiting prostate cancer bone metastases, and determining whether a conjugate is useful for such treatment are also provided. In some instances, the bisphosphonate is alendronate, and it is covalently bonded to either tartaric acid or glyceric acid.

Abstract: There is described a group of underquarternized anion exchange resins having the ability to bind with and remove from one environment to another a significant fraction of scavenged molecules by forming covalent bonds with the molecules. The method of using such underquarternized resins is also described.

Abstract: A method of forming a pharmaceutical composition of antimicrobial sterol conjugates having the following formulae: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Y are as defined in the specification. Also disclosed is a method of inducing an antimicrobial effect by administrating these pharmaceutical compositions.

Abstract: Described herein is a method, and the resulting compound, for the synthesis of improved amphiphilic antibiotic agents achieved by altering the chemical structure of amphiphilic polyene macrolide compounds with an oligo(ethylene glycol) conjugate in order to raise the critical micelle concentration of the compound.

Abstract: The invention discloses steroid conjugates having the following structure: ##STR1## where Y is NHCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, NH(CH.sub.2).sub.3 NH(CH.sub.2).sub.4 NH(CH.sub.2).sub.3 NH.sub.2, or NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NH.sub.2, and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is individually H, OH and OSO.sub.3 H. These conjugates posses antimicrobial properties and are, therefore, useful as antibiotics.

Abstract: An amphiphilic polymer, having the monomer unit structure A, B, C, or D: ##STR1## wherein R is at least one H and C.sub.1-6 alkyl, k=1-4, m=4-30, n=2-50 and x=2-500. ##STR2## wherein p and q are, independently, 0-22, and the sum of p and q is 4-22; ##STR3## wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds A, B, C and D is replaced by an amide, urea, urethane, ether or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.

Abstract: An amphiphilic polymer, having the monomer unit structure A, B, C or D: ##STR1## wherein R is at least one H and C.sub.1-6 alkyl, k=1-4, m=4-30, n=2-50 and x=2-500. ##STR2## wherein p and q are, independently, 0-22, and the sum of p and q is 4-22; ##STR3## wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds A, B, C and D is replaced by an amide, urea, urethane, ether or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.

Abstract: Compounds adapted to making polymerizable, cross linkable vesicles and methods for making these compounds comprising combining a phophatidylcholine derivative with an acid anhydride of a heterocyclic carbon/disulfide to form reaction products which when dispersed in aqueous buffer form vesicles that are readily polymerized by the addition of a reducing agent. The reduced vesicles form polymerized, highly cross-linked, vesicles which have a much greater stability and longer shelf life.

Abstract: Thiol containing lipids as provided which are used to construct polymerizable-deplymerizable vesicles that may be used as slow release in vivo medication delivery systems.

Abstract: Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.

Abstract: A method for the direct stepwise coating of a solid substrate with a polyfunctional polymerizable surfactant to provide a multilayer assembly of a plurality of oriented monolayers of polymerized surfactant on a surface of the solid substrate comprising depositing and polymerizing sequential layers of polymerizable surfactant on the substrate from a polymerization system comprising:(a) a polyfunctional polymerizable surfactant in an aqueous or other polar solvent system; and(b) a polyfunctional polymerizable surfactant in a non-polar organic solvent systemand wherein the sequential coatings are alternately effected from the (a) and (b) polymerization systems and the polymerizable surfactant utilized is the same or different for each sequential coating,and multilayered surfactant coated solid substrate products produced by this method.

Abstract: Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.