Patents by Inventor Steven L. Rose

Steven L. Rose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing liver fibrosis
    Patent number: 6986995
    Abstract: The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting ?2-macroglobulin (?2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of liver fibrosis in the individual based on the presence or level of ?2-MG, HA and TIMP-1.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: January 17, 2006
    Assignee: Prometheus Laboratories, Inc.
    Inventors: Steven L. Rose, Esther H. Oh, Michael J. Walsh
  • Methods of diagnosing liver fibrosis
    Publication number: 20030175686
    Abstract: The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting &agr;2-macroglobulin (&agr;2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of liver fibrosis in the individual based on the presence or level of &agr;2-MG, HA and TIMP-1.
    Type: Application
    Filed: February 28, 2002
    Publication date: September 18, 2003
    Inventors: Steven L. Rose, Esther H. Oh, Michael J. Walsh
  • Inflammatory bowel disease first step assay system
    Patent number: 6218129
    Abstract: The present invention provides a highly sensitive method of diagnosing inflammatory bowel disease (IBD) in an individual. The method includes the steps of isolating a sample from the individual; determining by non-histological means whether the sample is positive for anti-neutrophil cytoplasmic antibodies (ANCA); determining whether the sample is positive for anti-Saccharomyces cerevisiae immunoglobulin A (ASCA-IgA); determining whether the sample is positive for anti-Saccharomyces cerevisiae immunoglobulin G (ASCA-IgG); and diagnosing the individual as having IBD when the sample is positive for ANCA, ASCA-IgA or ASCA-IgG, and diagnosing the individual as not having IBD when the sample is negative for ANCA, ASCA-IgA and ASCA-IgG, provided that the method does not include histological analysis of neutrophils.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: April 17, 2001
    Assignee: Prometheus Laboratories, Inc.
    Inventors: Michael J. Walsh, Steven L. Rose