Abstract: The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity.

Abstract: A method is provided for using ?2? subunit calcium channel modulators or other compounds that interact with the ?2? calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, ?2? subunit calcium channel modulators include GABA analogs, e.g., gabapentin and pregabalin, fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, ?3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.

Abstract: The invention relates to methods of using sodium channel modulators, particularly TTX-R sodium channel modulators and/or activity dependent sodium channel modulators to treat a gastrointestinal tract disorders, particularly inflammatory bowel disorders and irritable bowel syndrome.

Abstract: The invention relates to a method of decreasing intestinal motility in a subject in need of treatment. The method comprises administering to the subject a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of decreasing intestinal motility in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. In certain embodiments, the subject is a subject with a functional bowel disorder, such as IBS, functional abdominal bloating, or functional diarrhea.

Abstract: A method is provided for using Cav2.2 subunit calcium channel modulators, particularly thiazolidinone, oxazolidinone, and imidazolone derivatives, to treat non-inflammatory gastrointestinal tract disorders.

Abstract: A system that provides a means for blind or visually impaired people to navigate through a complex environment using auditory cues. Two-way transceiver devices, held by the person, connect through a communications network to a computer system. The computer system activates appropriate auditory signals that are output from audio beacons located throughout the environment based on input provided through the transceiver. Additional interactivity can be incorporated into the system by means of the computer system.

Abstract: The present invention relates to method of treating a gastrointestinal motility disorder in a subject in need of treatment comprising coadministering to said subject a first amount of a compound having 5-HT3 receptor agonist activity or a pharmaceutically acceptable salt, hydrate or solvate thereof; and a second amount of at least one gastric acid suppressing agent (e.g., a proton pump inhibitor, an H2 receptor antagonist or a pharmaceutically acceptable salt, hydrate or solvate thereof; or an acid pump antagonist or pharmaceutically acceptable salt, hydrate or solvate thereof) wherein the first and second amounts together comprise a therapeutically effective amount. In particular, the method is for treating GERD, including nocturnal GERD.

Abstract: The invention relates to a method of treating functional bowel disorders in a subject in need of treatment. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating a functional bowel disorder in a subject in need thereof, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount. In addition, the method of the invention comprises administering a NARI alone. The functional bowel disorders which can be treated according to the method of the invention include IBS, functional abdominal bloating, functional constipation and functional diarrhea.

Abstract: A method is provided for using Cav2.2 subunit calcium channel modulators to treat non-inflammatory gastrointestinal tract disorders.

Abstract: The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity.

Abstract: The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity.

Abstract: Several commercial models relating to the payment for online content are disclosed herein. In lieu of prior art username/password combinations to gain access to exclusive on-line content, a tangible asset, namely a smart card, is used. Access is automatically granted when the smart card is inserted into a reader attached to the user's PC, and cut off when the smart card is removed from the reader. In this new model, the smart card provides a tangible, saleable, value-carrying asset that can be retailed, or otherwise distributed, which grants access to exclusive on-line content.

Abstract: A computer-based system permitting a visually impaired user to interact with tactile graphic-based interactive software applications is provided. The system includes a host computer having a data processor and a drive for running the interactive software applications and a pressure sensitive work pad. The work pad has X and Y pressure sensitive members disposed in a grid array for providing unique location output signals corresponding to each different location on the grid array. The work pad is operatively connected to the host computer and an overlay comprising a sheet is placed over an upper surface of the work pad. The overlay having a work space which bears tactile indicia which corresponds to a selected one of the interactive software applications and also includes a tactile graphical user interface (TGUI) formed thereon. The TGUI has a plurality of tactile control members which generate location output signals when pressed.

Abstract: A device and method for adding the perception of flavoring to a product that is consumed from a receptacle. The device is a cover for a receptacle, wherein a person can drink from a receptacle through the structure of the cover. At least a portion of the receptacle cover is scented with a desired fragrance. Furthermore, the scented portion of the receptacle cover enters the mouth when a person is drinking through the receptacle cover. As the scented portion of the receptacle cover is taken within the mouth, the receptacle cover scents the air contained within the mouth. By scenting the air inside the mouth, the nose is saturated by the desired fragrance and a more effective olfactory sense deception is obtained.

Abstract: A high temperature, short time microwave heating system 10 for heat-sensitive liquid material to inactivate or reduce pathogenic agents or organisms, such as viral contaminants. The system 10 includes a disposable cartridge 26 consisting of a preheater 32, a microwave heating coil 56 and cooler 58 with the heating coil 56 adapted to be easily inserted in and removed from the microwave heating field.

Abstract: A high temperature, short time microwave heating system 10 for heat-sensitive liquid material to inactivate or reduce pathogenic agents or organisms, such as viral contaminants. The system 10 includes a disposable cartridge 26 consisting of a preheater 32, a microwave heating coil 56 and cooler 58 with the heating coil 56 adapted to be easily inserted in and removed from the microwave heating field.

Abstract: A sanitary control back pressure diaphragm valve employed in a sanitary control system wherein the sanitary valve controls the pressure applied to a fluid in a sanitary contained system, which valve comprises: a valve body having an upper and lower valve member defining a generally conical fluid passageway and a valve seat, the members adapted to move between an open position and a closed position; a diaphragm support between the upper and lower members and a resilient diaphragm on the members on the diaphragm support to provide a seal between the upper and lower members and to provide for relative movement of said valve members between the open and closed valve position, the upper and lower valve members defining a generally conical valve passageway between the valve members, and the valve including a pressurized air inlet to provide controlled air pressure of one member; a sanitary fluid inlet extending in a straight line at an angle into the fluid passageway and a sanitary fluid outlet for the discharge of