Patents by Inventor Steven Le
Steven Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132913Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.Type: ApplicationFiled: September 4, 2023Publication date: April 25, 2024Applicants: OTTAWA HOSPITAL RESEARCH INSTITUTE, TURNSTONE BIOLOGICS CORP.Inventors: John C. Bell, Fabrice Le Boeuf, Michael S. Huh, Matthew Y. Tang, Adrian Pelin, Brian Andrew Keller, Caroline J. Breitbach, Michael F. Burgess, Steven H. Bernstein
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Patent number: 11954678Abstract: A system for communicating between blockchains on heterogeneous blockchain networks. The system can include a sending blockchain configured to transmit a first message via a sending blockchain protocol, wherein the sending blockchain forms a part of a sending blockchain network. The system can include a sending adapter node configured to receive the first message from the sending blockchain and translate the first message from the sending blockchain protocol to an adapter protocol. The system can include a receiving adapter node configured to receive the first message from the sending adapter node and translate the first message from the adapter protocol to a receiving blockchain protocol. The system can include a receiving blockchain configured to receive the first message from the receiving adapter node, and validate the first message, wherein the receiving blockchain forms a part of a receiving blockchain network.Type: GrantFiled: December 6, 2019Date of Patent: April 9, 2024Assignee: MASTERCARD INTERNATIONAL INCORPORATEDInventors: Sarala Buradagunta, Rakesh Yadav, Dmytro Kryvoshei, Steven C. Davis, Sébastien Le Callonnec
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Patent number: 11947899Abstract: The subject technology receives, from a document object model, a set of nodes of a web page, each node corresponding to an element of the web page. The subject technology determines, using an intersection observer, a position and visibility of a set of first elements within a viewport of the web page. The subject technology determines, using a mutation observer, a set of new elements within the viewport that was previously hidden and now visible. The subject technology provides a set of visible elements, based at least in part on the set of new elements and the set of first element, as elements that have been seen by a user during a session. The subject technology generates an index based at least in part on the set of visible elements, the index comprising information corresponding to text that was visible to the user during the session.Type: GrantFiled: May 31, 2023Date of Patent: April 2, 2024Assignee: Content Square SASInventors: Steven Botbol, Tristan Giovangrandi, Arnaud Bodenan, Henrique Cesar, Francois Le, Ryad Zenine
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Patent number: 11922415Abstract: A method of selectively locking a cryptographic digital asset includes instructing or requesting the creation or minting of a plurality of cryptographic tokens via a first common digital contract registered to a distributed ledger. Each cryptographic token is a digital asset that includes at least one attribute that is operative to evolve or change through a plurality of evolutionary stages. The plurality of cryptographic tokens are then instructed to be transferred to a plurality of token holders. The method further includes receiving a request from a token holder to selectively lock their digital asset at one of the plurality of evolutionary stages; and instructing or requesting the transfer of a second cryptographic token to the token holder, the second cryptographic token having at least one attribute that is at least partially derived from the evolutionary stage of the digital asset at the time of the request.Type: GrantFiled: April 21, 2023Date of Patent: March 5, 2024Assignee: NIKE, Inc.Inventors: Christopher Andon, Nikhil Gopalani, Chris Le Howard, Samuel Lespes, Benoit Pagotto, Steven Vasilev
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Publication number: 20210015906Abstract: The present disclosure relates to compositions and methods for treating Sanfilippo syndrome (also known as Sanfilippo disease type D, Sanfilippo D, mucopolysaccharidosis type IIID, MPS IIID). The method can entail injecting to the spinal fluid of a MPS IIID patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (GNS) protein comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and having the enzymatic activity of the human GNS protein. The composition can be provided in an artificial cerebrospinal fluid. About 1 mg to about 100 mg of the recombinant polypeptide may be administered to the patient once every 2 weeks to 6 months.Type: ApplicationFiled: July 1, 2020Publication date: January 21, 2021Inventors: Patricia Dickson, Tsui-Fen Chou, Sean Ekins, Shih-Hsin Kan, Steven Le, Derek R. Moen
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Publication number: 20180221459Abstract: The present disclosure relates to compositions and methods for treating Sanfilippo syndrome (also known as Sanfilippo disease type D, Sanfilippo D, mucopolysaccharidosis type IIID, MPS IIID). The method can entail injecting to the spinal fluid of a MPS IIID patient an effective amount of a composition comprising a recombinant human acetylglucosamine-6-sulfatase (GNS) protein comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1 and having the enzymatic activity of the human GNS protein. The composition can be provided in an artificial cerebrospinal fluid. About 1 mg to about 100 mg of the recombinant polypeptide may be administered to the patient once every 2 weeks to 6 months.Type: ApplicationFiled: April 5, 2018Publication date: August 9, 2018Inventors: Patricia Dickson, Tsui-Fen Chou, Sean Ekins, Shih-Hsin Kan, Steven Le, Derek R. Moen
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Publication number: 20180148704Abstract: The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: January 16, 2018Publication date: May 31, 2018Inventors: STEVEN LE, LING HUA, ROSALYN LAU, ZHEN QIAN, ZHEYONG YU
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Patent number: 9879245Abstract: The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: GrantFiled: December 2, 2013Date of Patent: January 30, 2018Assignee: DANISCO US INC.Inventors: Ling Hua, Rosalyn Lau, Steven Le, Zhen Qian, Zheyong Yu
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Publication number: 20170233707Abstract: The present compositions and methods relate to a beta-mannanase from Actinosynnema mirum, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: August 17, 2017Inventors: Steven LE, Zhen QIAN
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Publication number: 20170226494Abstract: The present compositions and methods relate to a beta-mannanase from Paenibacillus pabuli, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: August 10, 2017Inventors: Steven Le, Zhen Qian
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Publication number: 20170218351Abstract: The present compositions and methods relate to a beta-mannanase from Paenibacillus macerans, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: August 3, 2017Applicant: Danisco US Inc.Inventors: Steven Le, Zhen Qian
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Publication number: 20170211054Abstract: The present compositions and methods relate to a beta-mannanase from Paenibacillus polymyxa, polynucleotides encoding the beta-mannanase, and methods of making and/or using thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: July 27, 2017Inventors: Steven LE, Zhen QIAN
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Publication number: 20170211052Abstract: The present compositions and methods relate to a beta-mannanase from Mahella australiensis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: July 27, 2017Inventors: Steven Le, Zhen Qian
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Publication number: 20170211053Abstract: The present compositions and methods relate to a beta-mannanase from Streptococcus gallolyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: September 30, 2015Publication date: July 27, 2017Inventors: Steven Le, Zhen Qian
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Publication number: 20160186221Abstract: The present compositions and methods relate to a beta-mannanase from Paenibacillus kribbensis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: December 2, 2013Publication date: June 30, 2016Applicant: DANISCO US INC.Inventors: Ling HUA, Rosalyn LAU, Steven LE, Zhen QIAN, Zheyong YU
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Publication number: 20160115465Abstract: The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: December 2, 2013Publication date: April 28, 2016Applicant: Danisco US Inc.Inventors: Ling HUA, Rosalyn LAU, Steven LE, Zhen QIAN, Zheyong YU
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Publication number: 20150344923Abstract: The present compositions and methods relate to a beta-mannanase from Thermobifida fusca, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: December 2, 2013Publication date: December 3, 2015Applicant: DANISCO US INC.Inventors: Ling HUA, Rosalyn LAU, Steven LE, Zhen QIAN, Zheyong YU
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Publication number: 20150344922Abstract: The present compositions and methods relate to a beta-mannanase from Bacillus licheniformis, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).Type: ApplicationFiled: December 2, 2013Publication date: December 3, 2015Applicant: Danisco US Inc.Inventors: Ling HUA, Rosalyn LAU, Steven LE, Zhen QIAN, Zheyong YU
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Publication number: 20150176034Abstract: The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage.Type: ApplicationFiled: March 3, 2015Publication date: June 25, 2015Inventors: Kristoffer Ramos, Donna Santos, Padmavathy Desai, Prachand Shrestha, Richard Root Woods, Steven Le
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Publication number: 20150090714Abstract: A closure device for a fluid vessel can comprise a bistable valve arrangement which includes first and second valve rim portions and a valve member engageable with either of the rim portions respectively to define an open position in which fluid can exit the vessel and a closed position in which fluid is substantially prevented from exiting the vessel The valve can be arranged to close automatically when an impulse is exerted against the valve member. This can occur for example when the vessel is knocked over and the fluid therein exerts pressure against the valve member.Type: ApplicationFiled: December 10, 2014Publication date: April 2, 2015Inventors: Steven LE MASURIER, Stewart HUMPHREY, Darren PARSONS