Abstract: Exemplary embodiments include Ganoderma lucidum fungus designated as strains M2-100-02 and M2-102-02 as deposited with the ATCC Patent Depository under the Budapest Treaty (10801 University Blvd, Manassas, VA 20110), on Jul. 28, 2023, with the unofficial ATCC Patent Deposit Designation No. PTA-127609 (strain M2-100-02) and the unofficial ATCC Patent Deposit Designation No. PTA-127610 (strain M2-102-02), and the official deposit date of Jul. 28, 2023 and the official Patent Deposit Designation No PTA-127609 (strain M2-100-02) and the official Patent Deposit Designation No. PTA-127610 (strain M2-102-02). In some embodiments, the improved Ganoderma lucidum fungus designated as strains M2-100-02 and M2-102-02 are characterized by having optimized concentrations of bioactive compounds including Ganoderic acids and triterpines. In some embodiments, a Beta-glucan concentration is 20 percent or greater.

Abstract: Exemplary embodiments include a whole mycelium of Cordyceps militaris designated as strain M2-105-04 as deposited with the ATCC Patent Depository under the Budapest Treaty (10801 University Blvd, Manassas, VA 20110), on Jul. 28, 2023, with the unofficial ATCC Patent Deposit Designation No. PTA-127612 and the official deposit date of Jul. 28, 2023 and the official patent deposit number of PTA-127612. The whole mycelium is characterized by a phenotype having an abundance of fruiting bodies on top of a substrate and/or along a parameter of a bioreactor bag. It is also characterized by a phenotype having fruiting initiation at or near 18 days after inoculation, a phenotype having fruiting bodies maturing at or near 55 days after inoculation, and/or a phenotype having a 10-to-15-day colonization time on hulled oats.

Abstract: Embodiments of the present disclosure include Hericium erinaceus fungus designated as strain M2-102-10 as deposited with the ATCC Patent Depository under the Budapest Treaty (10801 University Blvd, Manassas, VA 20110), on Nov. 7, 2023, with the unofficial ATCC Patent Deposit Designation No. PTA-127680 and the official deposit date of ______ and the official Patent Deposit Designation No. ______. In some embodiments, the improved Hericium erinaceus fungus designated as strain M2-102-10 is characterized by having optimized concentrations of bioactive compounds. In some embodiments, a Beta-glucan concentration is 20 percent or greater.