Patents by Inventor Steven Lee Kuklish

Steven Lee Kuklish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BTK inhibitor compounds
    Patent number: 11542249
    Abstract: The invention provides BTK Inhibitor compounds of the formula pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using these compounds, salts, or compositions to treat autoimmune diseases such as Rheumatoid Arthritis.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: January 3, 2023
    Assignee: Eli Lilly and Company
    Inventors: Kenneth James Henry, Jr., Albert Khilevich, Steven Lee Kuklish, Katherine Marie Partridge, Steven James Quimby
  • BTK INHIBITOR COMPOUNDS
    Publication number: 20200290997
    Abstract: The invention provides BTK Inhibitor compounds, pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using these compounds, salts, or compositions to treat autoimmune diseases such as Rheumatoid Arthritis.
    Type: Application
    Filed: October 30, 2018
    Publication date: September 17, 2020
    Inventors: Kenneth James Henry, Jr., Albert Khilevich, Steven Lee Kuklish, Katherine Marie Partridge, Steven James Quimby
  • Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20180251446
    Abstract: The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.
    Type: Application
    Filed: May 8, 2018
    Publication date: September 6, 2018
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Katherine Marie Partridge, Jeremy Schulenburg York
  • Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20180250282
    Abstract: The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salt thereof, where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1
    Patent number: 9969714
    Abstract: The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 15, 2018
    Assignee: Eli Lilly and Company
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Katherine Marie Partridge, Jeremy Schulenburg York
  • Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin Esynthase-1
    Patent number: 9962375
    Abstract: The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 8, 2018
    Assignee: Eli Lilly and Company
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20170326128
    Abstract: The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 16, 2017
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Katherine Marie Partridge, Matthew Allen Schiffler, Alan M. Warshawsky, Jeremy Schulenburg York
  • Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
    Publication number: 20170313679
    Abstract: The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.
    Type: Application
    Filed: October 22, 2015
    Publication date: November 2, 2017
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Katherine Marie Partridge, Jeremy Schulenburg York
  • Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators
    Patent number: 9776964
    Abstract: The present invention provides a compound of the Formula (I): wherein X, R, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: October 3, 2017
    Assignee: Eli Lilly and Company
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Matthew Allen Schiffler, Alan M Warshawsky, Jeremy Schulenburg York
  • Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators
    Publication number: 20160272585
    Abstract: The present invention provides a compound of the Formula (I): wherein X, R, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2014
    Publication date: September 22, 2016
    Applicant: ELI LILLY AND COMPANY
    Inventors: Matthew Joseph Fisher, Steven Lee Kuklish, Peter Rudolph Manninen, Matthew Allen Schiffler, Alan M Warshawsky, Jeremy Schulenburg York
  • Dimethyl-benzoic acid compounds
    Patent number: 8642768
    Abstract: The present invention provides a compound of the Formula II: wherein A is: R1 is CH3, CF3, or F; R2 is H, CH3, or F; R3 is CH3, OCH3, OH, F; R4 is OH or CH2OH; and X is CH or N; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: February 4, 2014
    Assignee: Eli Lilly and Company
    Inventors: Maria-Jesus Blanco-Pillado, Matthew Joseph Fisher, Steven Lee Kuklish, Tatiana Natali Vetman
  • DIMETHYL-BENZOIC ACID COMPOUNDS
    Publication number: 20140005222
    Abstract: The present invention provides a compound of the Formula II: wherein A is: R1 is CH3, CF3, or F; R2 is H, CH3, or F; R3 is CH3, OCH3, OH, F; R4 is OH or CH2OH; and X is CH or N; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 20, 2013
    Publication date: January 2, 2014
    Inventors: Maria-Jesus BLANCO-PILLADO, Matthew Joseph FISHER, Steven Lee KUKLISH, Tatiana Natali VETMAN
  • Imidazole-2-benzamide compounds useful for the treatment of osteoarthritis
    Patent number: 8252831
    Abstract: The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: August 28, 2012
    Assignee: Eli Lilly and Company
    Inventors: Steven Lee Kuklish, Matthew Allen Schiffler, Jeremy Schulenburg York
  • Novel Imidazole-2-Benzamide Compounds Useful for the Treatment of Osteoarthritis
    Publication number: 20120157506
    Abstract: The present invention provides compounds of the formula below or pharmaceutical salts thereof, wherein R1, R2 and R3 are as described herein; methods of treating osteoarthritis using the compounds; and a process for preparing the compounds.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Steven Lee Kuklish, Matthew Allen Schiffler, Jeremy Schulenburg York
  • Substituted carboxamides
    Patent number: 7960419
    Abstract: This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: June 14, 2011
    Assignee: Eli Lilly and Company
    Inventors: Ryan Thomas Backer, Matthew Joseph Fisher, Sean Patrick Hollinshead, Steven Lee Kuklish, Edward C R Smith, Kumiko Takeuchi
  • SUBSTITUTED CARBOXAMIDES
    Publication number: 20090182025
    Abstract: This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.
    Type: Application
    Filed: June 7, 2007
    Publication date: July 16, 2009
    Inventors: Ryan Thomas Backer, Matthew Joseph Fisher, Sean Patrick Hollinshead, Steven Lee Kuklish, Edward C.R. Smith, Kumiko Takeuchi
  • Melanocortin receptor agonists
    Patent number: 7314879
    Abstract: The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: January 1, 2008
    Assignee: Eli Lilly and Company
    Inventors: Ryan Thomas Backer, Caño Ivan Collado, Oscar De Frutos-Garcia, Christopher William Doecke, Matthew Joseph Fisher, Steven Lee Kuklish, Vincent Mancuso, Michael John Martinelli, Jeffrey Thomas Mullaney, Paul Leslie Ornstein, Chaoyu Xie
  • Melanocortin receptor agonists
    Patent number: 7169777
    Abstract: The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: January 30, 2007
    Assignee: Eli Lilly and Company
    Inventors: Ryan Thomas Backer, Karin Briner, Ivan Collado Caño, Oscar De Frutos Garcia, Christopher William Doecke, Matthew Joseph Fisher, Cristina Garcia-Paredes, Steven Lee Kuklish, Vincent Mancuso, Michael John Martinelli, Ana Isabel Mateo Herranz, Jeffrey Thomas Mullaney, Paul Leslie Ornstein, Zhipei Wu, Chaoyu Xie
  • Substituted piperidines/piperazines as melanocortin receptor agonists
    Patent number: 7157463
    Abstract: The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: January 2, 2007
    Assignee: Eli Lilly and Company
    Inventors: Ryan Thomas Backer, Karin Briner, Christopher William Doecke, Matthew Joseph Fisher, Steven Lee Kuklish, Vincent Mancuso, Michael John Martinelli, Jeffrey Thomas Mullaney, Chaoyu Xie
  • Melanocortin receptor agonists
    Publication number: 20040116699
    Abstract: The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction 1
    Type: Application
    Filed: July 11, 2003
    Publication date: June 17, 2004
    Inventors: Ryan Thomas Backer, Karin Briner, Ivan Collado Cano, Oscar De Frutos Garcia, Christopher William Doecke, Matthew Joseph Fisher, Cristina Garcia-Paredes, Steven Lee Kuklish, Vincent Mancuso, Michael John Martinelli, Ana Isabel Mateo Herranz, Jeffrey Thomas Mullaney, Paul Leslie Ornstein, Zhipei Wu, Chaoyu Xie