Abstract: According to one embodiment, a method, computer system, and computer program product for tracking positions and characteristics of one or more individuals in proximity to a user to dynamically assess a threat of physiological harm to the user is provided. The present invention may include identifying, by one or more sensors integrated into one or more wearable devices on the person of a user, one or more individuals in proximity to the user; generating a dynamic threshold corresponding to each of the one or more individuals; responsive to identifying one or more characteristics of the individual, updating the dynamic threshold; and responsive to a distance between an individual of the one or more individuals and the user falling below the dynamic threshold associated with the individual, transmitting an alert to the user.

Abstract: Articles, such as sanitary tissue products, including fibrous structures, and more particularly articles including fibrous structures having a plurality of fibrous elements wherein the article exhibits differential cellulose content throughout the thickness of the article and methods for making same are provided.

Abstract: A tubing assembly is provided that can comprise a plurality of tubes or lumens that can be disposed within a head of a peristaltic pump. The tubing assembly can provide a flow rate or volume capacity that is generally equal to or greater than that achieved with a comparable prior art tube while operating at higher pressures than that possible using the prior art tube. Further, in accordance with some embodiments, the tubing assembly can achieve a longer working life than a comparable prior art tube, and the load on the pump motor can be reduced such that the pump life is increased and/or a larger pump motor is not required to achieve such advantageous results.

Abstract: The present invention relates to an isolated antibody, which selectively binds to CLEC14A, wherein said antibody (a) comprises at least one heavy chain variable region that comprises three CDRs and at least one light chain variable region that comprises three CDRs, wherein said heavy chain variable region comprises: (i) a variable heavy (VH) CDR1 that has the amino acid sequence of SEQ ID NO. 105, preferably of SEQ ID NO: 2 or 42; (ii) a VH CDR2 that has the amino acid sequence of SEQ ID NO. 106, preferably of SEQ ID NO: 3 or 43; and/or (iii) a VH CDR3 that has the amino acid sequence of SEQ ID NO. 107, preferably of SEQ ID NO: 4 or 44; and/or wherein said light chain variable region comprises: (iv) a variable light (VL) CDR1 that has the amino acid sequence of SEQ ID NO. 108, preferably of SEQ ID NO: 6 or 46; (v) a VL CDR2 that has the amino acid sequence of SEQ ID NO. 109, preferably of SEQ ID NO: 7 or 47; and/or (vi) a VL CDR3 that has the amino acid sequence of SEQ ID NO.

Abstract: A vibration appliance includes a vibration-isolation structure which substantially reduces vibration felt by the user at the handle. The vibration motor is mounted to a vibration plate which carries the massage node. The vibration plate floats within the vibration appliance housing, being suspended by a flexible, elastomer membrane having contours such as curves or folds in it that provide freedom of movement of the vibration plate relative to the housing to which the flexible membrane is mounted. This arrangement can be thought of as the motor and vibration node being mounted on a flexible diaphragm that can move freely as if mounted to the housing by a bellows-like arrangement.

Abstract: A computing system includes: processor(s), memory(s), storage device(s), and network interface(s) configured to communicate with data source(s) and remotely located computing device(s). The network interface(s) receives data regarding a digital product catalog representation of products from the data source(s). The processor(s): generates a respective score for the digital product catalog representation for each respective product, the score indicative of adherence of the digital product catalog representation for each respective product to at least one criterion; stores the respective score for the digital product catalog representation for each respective product using the at least one storage device; and identifies which products provide the greatest opportunity for sales improvement by improving adherence of the digital product catalog representation to the at least one criterion.

Abstract: The invention provides BTK Inhibitor compounds of the formula pharmaceutically acceptable salts, pharmaceutical compositions thereof, and methods of using these compounds, salts, or compositions to treat autoimmune diseases such as Rheumatoid Arthritis.

Abstract: The disclosure provides products configured for oral use, and methods of making the products. The products include a plurality of granules, the granules including at least one filler; at least one sugar alcohol; a cellulose ether, polyvinylpyrrolidone, or a combination thereof; and at least one active ingredient, at least one flavorant, or a combination thereof. The products may be in a granular form, or in the form of a tablet or pellet.

Abstract: A wet wipe that exhibits a novel combination of properties and methods for making such wet wipes are provided.

Abstract: Methods and systems for use of the Q-wave to R-wave interval to guide placement of a leadless cardiac pacemaker are disclosed. An implant delivery device is equipped with sensing electrodes to sense R-wave onset in a ventricle of a patient's heart to allow placement at a location of last or latest onset of the R-wave. Guidance tools are provided to assist in determination of the Q-wave to R-wave interval during implantation. For a chronic system, a cooperative approach is disclosed in which an implantable medical device and a leadless cardiac pacemaker exchange data to determine Q-wave to R-wave intervals and enhance cardiac resynchronization therapy delivery by the leadless cardiac pacemaker.

Abstract: A method of fabricating an integrated circuit (IC) includes forming a dielectric layer on a substrate having a plurality of the IC. A thin-film resistor (TFR) layer is deposited on the dielectric layer, and an underlayer (UL) including carbon is formed on the TFR layer. A hard mask layer including silicon is formed on the UL. Masked etching of the hard mask layer transfers a pattern of a photoresist layer onto the hard mask layer to form a hard mask layer pattern. Masked etching of the UL transfers the hard mask layer pattern onto the UL to form a UL pattern. Masked etching of the TFR layer transfers the UL pattern onto the TFR layer to form a TFR layer pattern including a matched pair of TFRs. The matched pair of TFRs are generally included in circuitry configured together for implementing at least one function.

Abstract: Pre-moistened fibrous structures containing filaments and solid additives, wherein the fibrous structures exhibit capacity values that are superior to known pre-moistened fibrous structures as measured according to the Capacity Test Method described herein and methods for making same are provided.

Abstract: Fibrous structures containing a mixture of three or more different fibrous elements (filaments and/or fibers) are provided.

Abstract: Fast-wetting (hydrophilic) coform fibrous structures, more particularly fast-wetting composite fibrous structures, for example dry fast-wetting composite fibrous structures, employing a wet-laid fibrous structure such as a paper web, and a coform fibrous structure, multi-ply fibrous structures, for example multi-ply sanitary tissue products such as multi-ply absorbent products for example multi-ply paper towel products, employing one or more fast-wetting composite fibrous structures, and methods for making same.

Abstract: Products configured for oral use and methods for preparing such products are provided. In particular, such products may be provided in the form of a lozenge. In some embodiments, oral products described herein may include a first sugar substitute in an amount of at least about 80 weight percent, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof. In one or more embodiments, at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both.

Abstract: An oral product configured for oral use is provided herein, the oral product including: at least one sugar substitute in an amount from about 25% to about 45% by weight, based on the total weight of the oral product; a gum in an amount from about 35% to about 55% by weight, based on the total weight of the oral product; a basic amine; and an organic acid, an alkali metal salt of an organic acid, or a combination thereof; wherein the organic acid has a log P value of from about 1.0 to about 12.0; wherein at least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof, the association in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or both; and wherein the oral product is in the form of a pastille.

Abstract: The disclosure provides a multi-layered tablet configured for oral use, the tablet including a first layer including an effervescent composition and a second layer including a non-effervescent composition. The effervescent composition includes an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; and at least one active ingredient. The non-effervescent composition includes one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; a binder; and a second active ingredient.

Abstract: A vibration appliance includes a vibration-isolation structure which substantially reduces vibration felt by the user at the handle. The vibration motor is mounted to a vibration plate which carries the massage node. The vibration plate floats within the vibration appliance housing, being suspended by a flexible, elastomer membrane having contours such as curves or folds in it that provide freedom of movement of the vibration plate relative to the housing to which the flexible membrane is mounted. This arrangement can be thought of as the motor and vibration node being mounted on a flexible diaphragm that can move freely as if mounted to the housing by a bellows-like arrangement.

Abstract: An oral product in the form of an edible film is provided herein. The edible film can include a binder in an amount of at least about 30 percent by weight; a plasticizer in an amount of at least about 5 percent by weight; and an active agent, wherein the edible film is orally dissolvable. The edible film can also be used as a component of another oral product, e.g., a fleece-based pouched product. The edible film can form a coating on a portion of an interior or exterior surface of a fleece-based pouched product.