Abstract: The present disclosure provides devices, systems, and methods for capturing and analyzing behavioral and physiological data of subjects for treatment, modification, and manipulation discovery. In some embodiments, a method for classifying a drug is provided. The method includes obtaining observational data concerning an animal subject to which the drug is administered, the observational data acquired using an enclosure for the animal subject, the enclosure instrumented with at least one sensing device. The method also includes extracting features by applying the observational data to a machine-learning feature-extraction component. The method further includes predicting a class label of the drug by applying the features to a machine-learning classifier component, the machine-learning classifier component trained to predict the class label of the drug from, at least in part, the features. The method further includes providing an indication of the class label.