Abstract: The invention relates to the use of ABIN2 to stabilise TPL-2, and a ternary complex formed between ABIN2, TPL-2 and p105, as well as assays for compounds capable of modulating the interaction between ABIN2 and TPL-2 and/or p105 and use of such compounds in the treatment of inflammatory conditions.

Abstract: A circuit and method thereof for sampling/holding signal is provided. The signal sampling/holding circuit comprises a first signal sampling/holding device, a second signal sampling/holding device, a target signal and a reference voltage. First, the first signal sampling/holding device is supplied with the reference voltage and the target signal. The reference voltage is disconnected from the first signal sampling/holding device before the target signal is. Similarly, the reference voltage is disconnected from the second signal sampling/holding device before the target signal is. Thus the target signal is respectively sampled and held in the first signal sampling/holding device and the second signal sampling/holding device.

Abstract: A frame shuttered CMOS image sensor with simultaneous array readout. An array of CMOS pixels are printed on a silicon substrate. Within each pixel is a light sensitive region comprising a photo sensitive diode for converting photons into electrical charge and at least three transistors to permit reading of reset electrical charges and collected electrical charges and for re-setting the photosensitive diode. The sensor includes an array of signal and re-set readout capacitors located on the substrate but outside of the pixel array. Metal conductors printed in said substrate connect each pixel in said pixel array with a signal capacitor and a re-set capacitor in array of signal and re-set readout capacitors. Transistor switches printed in said substrate but outside of said pixel array are used to isolate the signal and re-set capacitors from each other and from the pixels.

Abstract: To provide a catalyst for synthesis reaction which can achieve good yield in the Sonogashira reaction and also can be recovered after the reaction, and a method for synthesizing a compound in which the catalyst for synthesis reaction is used, a perovskite-type composite oxide containing palladium is used as the catalyst for synthesis reaction in the Sonogashira reaction represented by the following reaction scheme (1): R1—X+HC?CR2?R1C?CR2 ??(1)

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence thereof, wherein (i) at least two of the ligands are the same or different and are capable of being bound by ligand binding sites present on the CRP molecules; or (ii) at least one of the ligands is capable of being bound by a ligand binding site present on a CRP molecule, and at least one other of the ligands is capable of being bound by a ligand binding site present on a serum amyloid P component (SAP) molecule.

Abstract: A circuit and method thereof for sampling/holding signal is provided. The signal sampling/holding circuit comprises a first signal sampling/holding device, a second signal sampling/holding device, a target signal and a reference voltage. First, the first signal sampling/holding device is supplied with the reference voltage and the target signal. The reference voltage is disconnected from the first signal sampling/holding device before the target signal is. Similarly, the reference voltage is disconnected from the second signal sampling/holding device before the target signal is. Thus the target signal is respectively sampled and held in the first signal sampling/holding device and the second signal sampling/holding device.

Abstract: A catalyst for synthesis reaction that can allow the cross coupling reaction at an improved yield, and yet can be collected after used for the reaction and recycled, and a synthesizing method for a compound using the same catalyst for synthesis reaction.

Abstract: A common operational amplifier for a pipeline circuit is provided. The common operational amplifier is used by the stage circuits of the pipeline circuit by turns according to a predetermined timing. The common operational amplifier comprises an operational amplifier circuit, a multiplexer circuit and a demultiplexer circuit. The multiplexer circuit is provided for selecting a signal set of a stage circuit to be amplified to couple to the operational amplifier circuit, and the demultiplexer circuit is provided for transmitting the amplified signal set to the corresponding stage circuit.

Abstract: There is provided processes for metal mediated reactions, particularly cross coupling and carbometallation reactions, wherein the metal is present as a catalyst system comprising a catalyst microencapsulated within a permeable polymer microcapsule shell and the reaction is carried out under super-critical or near super-critical conditions. Preferred metal-mediated cross coupling reactions include Heck, Suzuki, Sonogashira and Stille reactions. Preferred carbometallation reactions include hydroformylations.

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: The present invention describes an apparatus and method for generating phonetico-prosodic parameters of a predetermined message starting from a source message. The predetermined message comprises carriers and phrases. The phonetico-prosodic parameters of the carriers and the phrases are stored in a memory after having been generated off-line. The invention also comprises an apparatus and method for electronically generating a spoken message starting from phonetico-prosodic parameters, stored in said memory. The carriers comprise fixed parts and open slots filled with arguments. The phonetico-prosodic parameters of the arguments to be filled in in the open slots are generated at run time.

Abstract: An improved apparatus for generating a spoken message is of the type formed by (i) first recording speech and (ii) then utilizing the recording so as to obtain at least one carrier, each carrier having at least one fixed part and at least one open slot, and then (iii) inserting an argument into each open slot. The improvement provides a phonetico-prosodic parameter generator for characterizing the message in terms of a sequence of phonetico-prosodic parameters for each carrier. An electronic memory stores the phonetico-prosodic parameters corresponding to each carrier and a controller constructs sequences of phonetico-prosodic parameters corresponding to the argument of each open slot. From the phonetico-prosodic parameters, a phonetics-to-speech converter generates a digital sound wave pattern which is converted, by a D/A converter, into an analog sound wave pattern. An output unit provides audible sound waves corresponding to the analog sound wave pattern.

Abstract: An improved method for generating a spoken message is of the type formed by (i) first recording speech and (ii) then utilizing the recording so as to obtain at least one carrier, each carrier having at least one fixed part and at least one open slot, and then (iii) inserting an argument into each open slot. The improvement involves applying a prosody transplantation technique to the recording in order to obtain a sequence of phonetico-prosodic parameters for each carrier; identifying in each sequence sections of phonetico-prosodic parameters corresponding to the argument of each open slot; and substituting each of the sections by open slot data comprising at least position information indicating the position of each open slot.