Abstract: The invention relates to the use of ABIN2 to stabilise TPL-2, and a ternary complex formed between ABIN2, TPL-2 and p105, as well as assays for compounds capable of modulating the interaction between ABIN2 and TPL-2 and/or p105 and use of such compounds in the treatment of inflammatory conditions.

Abstract: To provide a catalyst for synthesis reaction which can achieve good yield in the Sonogashira reaction and also can be recovered after the reaction, and a method for synthesizing a compound in which the catalyst for synthesis reaction is used, a perovskite-type composite oxide containing palladium is used as the catalyst for synthesis reaction in the Sonogashira reaction represented by the following reaction scheme (1): R1—X+HC?CR2?R1C?CR2 ??(1)

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence thereof, wherein (i) at least two of the ligands are the same or different and are capable of being bound by ligand binding sites present on the CRP molecules; or (ii) at least one of the ligands is capable of being bound by a ligand binding site present on a CRP molecule, and at least one other of the ligands is capable of being bound by a ligand binding site present on a serum amyloid P component (SAP) molecule.

Abstract: A catalyst for synthesis reaction that can allow the cross coupling reaction at an improved yield, and yet can be collected after used for the reaction and recycled, and a synthesizing method for a compound using the same catalyst for synthesis reaction.

Abstract: There is provided processes for metal mediated reactions, particularly cross coupling and carbometallation reactions, wherein the metal is present as a catalyst system comprising a catalyst microencapsulated within a permeable polymer microcapsule shell and the reaction is carried out under super-critical or near super-critical conditions. Preferred metal-mediated cross coupling reactions include Heck, Suzuki, Sonogashira and Stille reactions. Preferred carbometallation reactions include hydroformylations.

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: A high quality speech synthesizer in various embodiments concatenates speech waveforms referenced by a large speech database. Speech quality is further improved by speech unit selection and concatenation smoothing.

Abstract: The present invention describes an apparatus and method for generating phonetico-prosodic parameters of a predetermined message starting from a source message. The predetermined message comprises carriers and phrases. The phonetico-prosodic parameters of the carriers and the phrases are stored in a memory after having been generated off-line. The invention also comprises an apparatus and method for electronically generating a spoken message starting from phonetico-prosodic parameters, stored in said memory. The carriers comprise fixed parts and open slots filled with arguments. The phonetico-prosodic parameters of the arguments to be filled in in the open slots are generated at run time.

Abstract: An improved apparatus for generating a spoken message is of the type formed by (i) first recording speech and (ii) then utilizing the recording so as to obtain at least one carrier, each carrier having at least one fixed part and at least one open slot, and then (iii) inserting an argument into each open slot. The improvement provides a phonetico-prosodic parameter generator for characterizing the message in terms of a sequence of phonetico-prosodic parameters for each carrier. An electronic memory stores the phonetico-prosodic parameters corresponding to each carrier and a controller constructs sequences of phonetico-prosodic parameters corresponding to the argument of each open slot. From the phonetico-prosodic parameters, a phonetics-to-speech converter generates a digital sound wave pattern which is converted, by a D/A converter, into an analog sound wave pattern. An output unit provides audible sound waves corresponding to the analog sound wave pattern.

Abstract: An improved method for generating a spoken message is of the type formed by (i) first recording speech and (ii) then utilizing the recording so as to obtain at least one carrier, each carrier having at least one fixed part and at least one open slot, and then (iii) inserting an argument into each open slot. The improvement involves applying a prosody transplantation technique to the recording in order to obtain a sequence of phonetico-prosodic parameters for each carrier; identifying in each sequence sections of phonetico-prosodic parameters corresponding to the argument of each open slot; and substituting each of the sections by open slot data comprising at least position information indicating the position of each open slot.