Abstract: A imaging device includes a light source, a detector, and an optical polarization system for video imaging of superficial biological tissue layers. The device relies on taking a set of measurements at different polarization orientations so as to render a new image that is independent of the light reflected from the surface of a tissue sample and that is independent of the light scattered from deep tissue layers. The device may comprise multiple light sources or multiple light detectors. The light source may provide light in a variety of forms such as coherent light and modulated light. Optical devices such as beam splitters, lens and mirrors may be utilized to allow images to be acquired along different light paths.

Abstract: A video imaging device includes a light source, a detector, and an optical polarization system for video imaging of superficial biological tissue layers. The device relies on taking a set of measurements at different polarization orientations so as to render a new image that is independent of the light reflected from the surface of a tissue sample and that is independent of the light scattered from deep tissue layers.

Abstract: A multiple diameter fiber optic device comprises one or more optical fibers that are used to irradiate light onto a tissue and to detect light back-scattered by the tissue wherein each fiber is used for both irradiation and detection. In the case of multiple fibers, the fibers typically are bundled together at the probe end of the bundle. The diameters and/or numerical apertures of the one or more fibers are selected to provide different sampling volumes within the tissue. More specifically, the diameter and/or numerical apertures of the one or more fibers are chosen to emphasize differences in light penetration into the tissue such that the diameter and/or numerical aperture of each fiber is related to the scattering and absorption path lengths in the tissue.