Patents by Inventor Steven M. Ansell

Steven M. Ansell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20250034081
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: April 18, 2024
    Publication date: January 30, 2025
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids for use in lipid nanoparticle formulations
    Patent number: 12129223
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: October 29, 2024
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell, Jason Samuel Tan, Polina Blagojevic, Stephen Paul Arns, Julia Gatenyo
  • NOVEL CARBONYL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20240122854
    Abstract: Compounds are provided having one of the following structures (I) or or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G1b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 18, 2024
    Inventors: Xinyao Du, Steven M. Ansell
  • NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20240075163
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 24, 2023
    Publication date: March 7, 2024
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230372537
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: November 23, 2023
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11820728
    Abstract: Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: November 21, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Xinyao Du, Steven M. Ansell
  • LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230295075
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: December 15, 2022
    Publication date: September 21, 2023
    Inventors: Xinyao Du, Steven M. Ansell, Jason Samuel Tan, Polina Blagojevic, Stephen Paul Arns, Julia Gatenyo
  • Lipid nanoparticle formulations
    Patent number: 11712481
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 1, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11648324
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: May 16, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11634379
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: April 25, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220204439
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 7, 2021
    Publication date: June 30, 2022
    Inventors: Xinyao Du, Steven M. Ansell
  • Lipids for delivery of active agents
    Patent number: 11357856
    Abstract: Compounds are provided having the following structure: Formula (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, G1, G2 and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: June 14, 2022
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Steven M. Ansell, Xinyao Du
  • NOVEL CARBONYL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220081392
    Abstract: Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: April 27, 2018
    Publication date: March 17, 2022
    Inventors: Xinyao DU, Steven M. ANSELL
  • NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220072155
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: May 11, 2021
    Publication date: March 10, 2022
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF ACTIVE AGENTS
    Publication number: 20210395188
    Abstract: Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein G1, R1, R2, L, and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 23, 2021
    Inventor: Steven M. ANSELL
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11168051
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 9, 2021
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Xinyao Du, Steven M. Ansell
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 11040112
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: June 22, 2021
    Assignee: ACUITAS THERAPEUTICS, INC.
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20210107861
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: June 19, 2020
    Publication date: April 15, 2021
    Inventors: Steven M. Ansell, Xinyao Du
  • Lipids and lipid nanoparticle formulations for delivery of nucleic acids
    Patent number: 10723692
    Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 28, 2020
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Steven M. Ansell, Xinyao Du
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20200121809
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: October 26, 2017
    Publication date: April 23, 2020
    Inventors: Michael J. Hope, Barbara Mui, Jia Ching Paulo Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du