Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.

Abstract: Systems and methods are provided for splicing airframe components. One embodiment is a method for assembling an airframe of an aircraft. The method includes forming a first skin of a first circumferential section of fuselage, the first skin including a distal portion comprising a lip and a shoulder, aligning a second skin of a second circumferential section of fuselage with the shoulder such that the lip overlaps the second skin, and affixing the first skin and the second skin together via a circumferential splice.

Abstract: A computer system may manage orders for goods from a plurality of purchasers. The computer system may receive the orders, calculate an approximate volume that the goods which are the subject of each order would collectively occupy during shipment, and compare each calculated approximate volume to a pre-determine maximum allowed volume that the purchaser of the order is permitted. The computer system may accept each order whose approximate volume does not exceed the maximum allowed volume for the purchaser of the order, or reject each order whose approximate volume exceeds this maximum allowed volume.

Abstract: A computer system may manage orders for goods from a plurality of purchasers. The computer system may receive the orders, calculate an approximate volume that the goods which are the subject of each order would collectively occupy during shipment, and compare each calculated approximate volume to a pre-determine maximum allowed volume that the purchaser of the order is permitted. The computer system may accept each order whose approximate volume does not exceed the maximum allowed volume for the purchaser of the order, or reject each order whose approximate volume exceeds this maximum allowed volume.