Patents by Inventor Steven M. Finkbeiner

Steven M. Finkbeiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220187280
    Abstract: Genetically encoded death indicator (GEDI) polypeptides and nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides to monitor cell death events in vitro and in vivo, particularly in neuronal cell death, are also provided.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Jeremy Linsley, Kevan Shah, Steven M. Finkbeiner
  • Patent number: 11361527
    Abstract: The present disclosure provides automated robotic microscopy systems that facilitate high throughput and high content analysis of biological samples, such as living cells and/or tissues. In certain aspects, the systems are configured to reduce user intervention relative to existing technologies, and allow for precise return to and re-imaging of the same field (e.g., the same cell) that has been previously imaged. This capability enables experiments and testing of hypotheses that deal with causality over time with greater precision and throughput than conventional microscopy methods.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: June 14, 2022
    Assignee: The J. David Gladstone Institutes
    Inventors: Steven M. Finkbeiner, Dale Michael Ando, Aaron C. Daub
  • Patent number: 10611741
    Abstract: The present invention relates to substituted benzoxazines and related compounds and derivatives thereof and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 7, 2020
    Assignee: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
    Inventors: Andrey S. Tsvetkov, Steven M. Finkbeiner, Michael A. Pleiss, Robert Greenhouse
  • Publication number: 20200089986
    Abstract: The present disclosure provides automated robotic microscopy systems that facilitate high throughput and high content analysis of biological samples, such as living cells and/or tissues. In certain aspects, the systems are configured to reduce user intervention relative to existing technologies, and allow for precise return to and re-imaging of the same field (e.g., the same cell) that has been previously imaged. This capability enables experiments and testing of hypotheses that deal with causality over time with greater precision and throughput than conventional microscopy methods.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 19, 2020
    Inventors: Steven M. Finkbeiner, Dale Michael Ando, Aaron C. Daub
  • Patent number: 10474920
    Abstract: The present disclosure provides automated robotic microscopy systems that facilitate high throughput and high content analysis of biological samples, such as living cells and/or tissues. In certain aspects, the systems are configured to reduce user intervention relative to existing technologies, and allow for precise return to and re-imaging of the same field (e.g., the same cell) that has been previously imaged. This capability enables experiments and testing of hypotheses that deal with causality over time with greater precision and throughput than conventional microscopy methods.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: November 12, 2019
    Assignee: The J. David Gladstone Institutes
    Inventors: Steven M. Finkbeiner, Dale Michael Ando, Aaron C. Daub
  • Publication number: 20190242876
    Abstract: Genetically encoded death indicator (GEDI) polypeptides and nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides to monitor cell death events in vitro and in vivo, particularly in neuronal cell death, are also provided.
    Type: Application
    Filed: October 18, 2017
    Publication date: August 8, 2019
    Inventors: Jeremy Linsley, Kevan Shah, Steven M. Finkbeiner
  • Publication number: 20190106394
    Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: August 17, 2018
    Publication date: April 11, 2019
    Inventors: Andrey S. Tsvetkov, Steven M. Finkbeiner, Michael A. Pleiss, Robert Greenhouse
  • Patent number: 10087151
    Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: October 2, 2018
    Assignee: THE J. DAVID GLADSTONE INSTITUTES, A TESTIMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE
    Inventors: Andrey S. Tsvetkov, Steven M. Finkbeiner, Michael A. Pleiss, Robert Greenhouse
  • Publication number: 20160354372
    Abstract: The present disclosure provides methods for treating neurological disorders, generally involving modulating protein kinase D1 (PKD1) activity levels in a neuron or glial cell in an individual in need thereof. The present disclosure provides antibodies specific for PKD1. The present disclosure provides a genetically modified non-human mammal deficient in PKD1 activity.
    Type: Application
    Filed: May 5, 2016
    Publication date: December 8, 2016
    Inventors: Steven M. Finkbeiner, Vikram Ramnath Rao, Sarah Rosemary Carter, Eva Suzanne LaDow, Hong Joo Kim, Matthew Campioni
  • Publication number: 20160326123
    Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: January 8, 2015
    Publication date: November 10, 2016
    Applicant: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLAD
    Inventors: Andrey S. Tsvetkov, Steven M. Finkbeiner, Michael A. Pleiss, Robert Greenhouse
  • Patent number: 9359445
    Abstract: The present disclosure provides methods for treating neurological disorders, generally involving modulating protein kinase D1 (PKD1) activity levels in a neuron or glial cell in an individual in need thereof. The present disclosure provides antibodies specific for PKD1. The present disclosure provides a genetically modified non-human mammal deficient in PKD1 activity.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: June 7, 2016
    Assignee: The J. David Gladstone Institutes
    Inventors: Steven M. Finkbeiner, Vikram Ramnath Rao, Sarah Rosemary Carter, Eva Suzanne LaDow, Hong Joo Kim, Matthew Campioni
  • Publication number: 20150278625
    Abstract: The present disclosure provides automated robotic microscopy systems that facilitate high throughput and high content analysis of biological samples, such as living cells and/or tissues. In certain aspects, the systems are configured to reduce user intervention relative to existing technologies, and allow for precise return to and re-imaging of the same field (e.g., the same cell) that has been previously imaged. This capability enables experiments and testing of hypotheses that deal with causality over time with greater precision and throughput than conventional microscopy methods.
    Type: Application
    Filed: June 11, 2015
    Publication date: October 1, 2015
    Inventors: Steven M. Finkbeiner, Dale Michael Ando, Aaron C. Daub
  • Publication number: 20080096980
    Abstract: The present invention provides a method of reducing a level of a toxic protein in the cytosol of a cell, the method generally involving contacting the cell with an agent that induces a survival response by the cell. The present invention provides a method of reducing a level of a toxic protein in a cell, the method generally involving contacting the cell with an agent that induces sequestration of the toxic protein in an inclusion body in the cell. The present invention further provides methods of identifying an agent that induces sequestration of a toxic protein into an inclusion body. The present invention further provides methods of increasing the yield of a recombinant protein synthesized by a genetically modified prokaryotic or eukaryotic host cell.
    Type: Application
    Filed: September 7, 2005
    Publication date: April 24, 2008
    Inventors: Steven M. Finkbeiner, Siddhartha Mitra, Montserrat Arrasate
  • Patent number: 7139415
    Abstract: The invention comprises a robotic microscope system and methods that allow high through-put analysis biological materials, particularly living cells, and allows precise return to and re-imaging of the same field (e.g., the same cell) that has been imaged earlier. This capability enables experiments and testing hypotheses that deal with causality over time intervals which are not possible with conventional microscopy methods.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: November 21, 2006
    Assignee: The Regents of the University of California
    Inventor: Steven M. Finkbeiner
  • Publication number: 20030103662
    Abstract: The invention comprises a robotic microscope system and methods that allow high through-put analysis biological materials, particularly living cells, and allows precise return to and re-imaging of the same field (e.g., the same cell) that has been imaged earlier. This capability enables experiments and testing hypotheses that deal with causality over time intervals which are not possible with conventional microscopy methods.
    Type: Application
    Filed: December 5, 2002
    Publication date: June 5, 2003
    Inventor: Steven M. Finkbeiner