Patents by Inventor Steven M. Hannick

Steven M. Hannick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retroviral protease inhibiting compounds
    Patent number: 7968707
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 28, 2011
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6- DIAZABICYCLO[3.2.0]HEPTANE
    Publication number: 20090203664
    Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
    Type: Application
    Filed: April 20, 2009
    Publication date: August 13, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael J. Buckley, Jianguo Ji, Geoff G.Z. Zhang, Rodger F. Henry, Weili W. Wang, Gregory S. Wayne, Wenke Li, Timothy B. Towne, Steven J. Wittenberger, Steven M. Hannick, Brian J. Kotecki, Bryan S. Macri, Timothy A. Robbins
  • (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane
    Patent number: 7538226
    Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: May 26, 2009
    Assignee: Abbott Laboratories
    Inventors: Michael J. Buckley, Jianguo Ji, Geoff G. Z. Zhang, Rodger F. Henry, Weili W. Wang, Gregory S. Wayne, Wenke Li, Timothy B. Towne, Steven J. Wittenberger, Steven M. Hannick, Brian J. Kotecki, Bryan S. Macri, Timothy A. Robbins
  • (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane
    Patent number: 7354937
    Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: April 8, 2008
    Assignee: Abbott Laboratories
    Inventors: Michael J. Buckley, Jianguo Ji, Geoff G. Z. Zhang, Rodger F. Henry, Weili W. Wang, Gregory S. Wayne, Wenke Li, Timothy B. Towne, Steven J. Wittenberger, Steven M. Hannick, Brian J. Kotecki, Bryan S. Macri, Timothy A. Robbins
  • Synthesis of acyclic nucleoside derivatives
    Patent number: 7189849
    Abstract: Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: March 13, 2007
    Assignee: Medivir AB
    Inventors: M. Robert Leanna, Michael Rasmussen, Steven M. Hannick, Jien-Heh J. Tien, Kirill A. Lukin, Zhenping Tian, Sou-Jen Chang, Cynthia B. Curty, Bikshandarkoil A. Narayanan, John Bellettini, Bhadra Shelat, Tiffany Spitz
  • Synthesis of acyclic nucleoside derivatives
    Publication number: 20040248910
    Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: December 9, 2004
    Applicant: Medivir AB
    Inventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
  • Synthesis of acyclic nucleoside derivatives
    Patent number: 6613936
    Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: September 2, 2003
    Assignee: Medivir AB
    Inventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Howard Morton, Daniel Plata
  • Retroviral protease inhibiting compounds
    Publication number: 20030100755
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: October 25, 2002
    Publication date: May 29, 2003
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Patent number: 6472529
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: October 29, 2002
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Publication number: 20020004503
    Abstract: A compound of the formula: 1
    Type: Application
    Filed: April 18, 2001
    Publication date: January 10, 2002
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Retroviral protease inhibiting compounds
    Patent number: 6313296
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: November 6, 2001
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Synthesis of acyclic nucleoside derivatives
    Patent number: 6184376
    Abstract: Methods and novel intermediates of the formula: wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2CH2—, R8 is C1-C21 alkyl or a C2-C21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, C1-C6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: February 6, 2001
    Assignee: Mediver AB
    Inventors: M. Robert Leanna, Steven M. Hannick, Michael Rasmussen, Jien-Heh J. Tien, Lakshmi Bhagavatula, Pulla Reddy Singam, Bradley D. Gates, Lawrence Kolaczkowski, Ramesh R. Patel, Greg Wayne, Greg Lannoye, Weijiang Zhang, Zhenping Tian, Kirill A. Lukin, Bikshandarkoil A. Narayanan, David A. Riley, Howard Morton, Sou-Jen Chang, Cynthia B. Curty, Daniel Plata, John Bellettini, Bhadra Shelat, Tiffany Spitz, Cheng-Xi Yang
  • Process for preparing substituted cyclobutanes
    Patent number: 5399775
    Abstract: The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: March 21, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty
  • Process for the preparation of a substituted diaminodiol
    Patent number: 5362912
    Abstract: A process is disclosed for the preparation of a substituted diaminodiol.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: November 8, 1994
    Assignee: Abbott Laboratories
    Inventors: Thomas J. Sowin, Steven M. Hannick, Elizabeth M. Doherty, Takahiro Sato, Takayuki Suzuki
  • Process for preparing substituted cyclobutanes
    Patent number: 5312963
    Abstract: The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: May 17, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty
  • Carbocyclic nucleoside analogs
    Patent number: 5246931
    Abstract: A compound of the formula: ##STR1## wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH.sub.2 OH or --OH; and G and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl, --OH, --CH.sub.2 OH, --CH.sub.2 OR.sub.20 wherein R.sub.20 is C.sub.1 to C.sub.6 alkyl, --CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is C.sub.1 to C.sub.10 alkyl, --CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 is the side chain of any of the naturally occurring amino acids and R.sub.23 is hydrogen or --C(O)CH(R.sub.24)(NH.sub.2) wherein a R.sub.24 is the side chain of any of the naturally occurring amino acids, --CH.sub.2 SH, --CH.sub.2 Cl, --CH.sub.2 F, --CH.sub.2 Br, --CH.sub.2 I, --C(O)H, --CH.sub.2 CN, --CH.sub.2 N.sub.3, --CH.sub.2 NR.sub.1 R.sub.2, --CO.sub.2 R.sub.1, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OR.sub.20 wherein R.sub.20 is as defined above, --CH.sub.2 CH.sub.2 OC(O)R.sub.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: September 21, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel W. Norbeck, Jacob J. Plattner, Terry J. Rosen, David L. Garmaise, Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin
  • Process for preparing substituted cyclobutane purines
    Patent number: 5235052
    Abstract: The present invention relates to a process for the preparation of substantially pure enantiomer of the purines substituted with cyclobutanes.
    Type: Grant
    Filed: March 11, 1991
    Date of Patent: August 10, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty
  • Process for preparation of intermediates of carbocyclic nucleoside analogs
    Patent number: 5153352
    Abstract: A compound of the formula: ##STR1## wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH.sub.2 OH or --OH; and G and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl, --OH, --CH.sub.2 OH, --CH.sub.2 OR.sub.20 wherein R.sub.20 is C.sub.1 to C.sub.6 alkyl, --CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is C.sub.1 to C.sub.10 alkyl, --CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 is the side chain of any of the naturally occuring amino acids and R.sub.23 is hydrogen or --C(O)CH(R.sub.24)(NH.sub.2) wherein R.sub.24 is the side chain of any of the naturally occuring amino acids, --CH.sub.1 SH, --Ch.sub.2 Cl, --Ch.sub.2 F, --CH.sub.2 Br, --CH.sub.2 I, --C(O)H, --CH.sub.2 CN, --CH.sub.2 N.sub.3, --CH.sub.2 NR.sub.1 R.sub.2, --CO.sub.2 R.sub.1, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OR.sub.20 wherein R.sub.20 is as defined above, --CH.sub.2 CH.sub.2 OC(O)R.sub.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: October 6, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel W. Norbeck, Richard J. Pariza, Steven M. Hannick, Thomas J. Sowin
  • Semisynthetic erythromycin antibiotics
    Patent number: 4740502
    Abstract: Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. Certain 4"-carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced gastrointestinal stimulation compared to the parent compounds.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: April 26, 1988
    Assignee: Abbott Laboratories
    Inventors: Steven M. Hannick, Larry L. Klein