Patents by Inventor Steven M. Hersch

Steven M. Hersch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH-SENSITIVITY IMMUNOASSAY FOR THE DETECTION OF FRATAXIN IN BIOFLUIDS
    Publication number: 20220308072
    Abstract: Disclosed herein are methods for assaying the concentration of frataxin in biofluids, and kits, reagents, and uses thereof.
    Type: Application
    Filed: August 11, 2020
    Publication date: September 29, 2022
    Inventors: Steven M. HERSCH, Shawn CIOTTI
  • COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20220275367
    Abstract: The present disclosure relates to pharmaceutical compositions of adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
    Type: Application
    Filed: July 24, 2020
    Publication date: September 1, 2022
    Inventors: Dinah Wen-Yee Sah, Pengcheng Zhou, Jeffrey S. Thompson, Christina Gamba-Vitalo, Jenna Carroll Soper, Steven M. Hersch, Todd Carter, Jacob J. Cardinal, Lori B. Karpes, Bin Liu
  • CANNULA SYSTEM AND USE THEREOF
    Publication number: 20210361318
    Abstract: The present disclosure relates to cannula systems for delivery of a therapeutic agent to parenchymal tissue of a target subject. In certain embodiments, the cannula system is for delivery of a therapeutic agent to parenchymal tissue in the spine of a target subject. In certain embodiments, the cannula system includes a cannula positioning guide (CPG) useful in the delivery of a therapeutic agent to a localized target tissue of a subject. The guide may be used in a surgical suite or during a surgical procedure.
    Type: Application
    Filed: July 2, 2019
    Publication date: November 25, 2021
    Inventors: Holger Patzke, Steven M. Hersch, Jenna Carroll Soper, Adrian Philip Kells, Nicholas Boulis, Donna T. Ward
  • SYSTEMS AND METHODS FOR PRODUCING GENE THERAPY FORMULATIONS
    Publication number: 20210355454
    Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles and AAV formulations, including recombinant adeno-associated virus (rAAV) particles and formulations. In certain embodiments, the present disclosure presents methods and systems for clarifying, purifying, formulating, filtering and processing AAV particles and AAV formulations. The present disclosure also describes compositions, methods and processes for the design, preparation, manufacture, use and/or formulation of AAV particles comprising modulatory polynucleotides, e.g., polynucleotides encoding small interfering RNA (siRNA) molecules which target the Huntingtin (HTT) gene (e.g., the wild-type or the mutated CAG-expanded HTT gene). Methods for using formulated AAV particles comprising modulatory polynucleotides to inhibit the HTT gene expression in a subject with a neurodegenerative disease (e.g., Huntington's Disease (HD)) are also disclosed.
    Type: Application
    Filed: July 24, 2019
    Publication date: November 18, 2021
    Inventors: Jacob J. Cardinal, Robert Steininger, Lori B. Karpes, Christopher J. Morrison, Daniel S. Hurwit, Matthew Luther, Andrew M. Wood, Dinah Wen-Yee Sah, Pengcheng Zhou, Jeffrey S. Thompson, Christina Gamba-Vitalo, Jenna Carroll Soper, Steven M. Hersch, Todd Carter
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND DISORDERS ASSOCIATED WITH THE SPINAL CORD
    Publication number: 20210254103
    Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.
    Type: Application
    Filed: July 2, 2019
    Publication date: August 19, 2021
    Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Jenna Carroll Soper, Holger Patzke, Jinzhao Hou, Steven M. Hersch
  • COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES
    Publication number: 20140336178
    Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
    Type: Application
    Filed: April 29, 2014
    Publication date: November 13, 2014
    Applicants: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Aleksey G. Kazantsev, Anne B. Young, David E. Housman, Steven M. Hersch