Patents by Inventor Steven M. Opal

Steven M. Opal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detoxified endotoxin immunogenic compositions and uses thereof
    Patent number: 9616116
    Abstract: The present invention provides an immunogenic composition of a lipopolysaccharide vaccine and a non-alum adjuvant. The immunogenic composition may be detoxified J5 core lipopolysaccharide of Escherichia coli non-covalently complexed with group B meningococcal outermembrane protein. Also provided are methods for preventing an infection caused by a Gram-negative bacteria in an individual via administering the immunogenic compositions to the individual.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: April 11, 2017
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, THE MEMORIAL HOSPITAL OF RHODE ISLAND, UNITED STATES ARMY
    Inventors: Alan S. Cross, Apurba K. Bhattacharjee, Wendell D. Zollinger, Steven M. Opal
  • Detoxified Endotoxin Immunogenic Compositions and Uses Thereof
    Publication number: 20150174228
    Abstract: The present invention provides an immunogenic composition of a lipopolysaccharide vaccine and a non-alum adjuvant. The immunogenic composition may be detoxified J5 core lipopolysaccharide of Escherichia coli non-covalently complexed with group B meningococcal outermembrane protein. Also provided are methods for preventing an infection caused by a Gram-negative bacteria in an individual via administering the immunogenic compositions to the individual.
    Type: Application
    Filed: March 3, 2015
    Publication date: June 25, 2015
    Applicants: UNIVERSITY OF MARYLAND, BALTIMORE, THE MEMORIAL HOSPITAL OF RHODE ISLAND, UNITED STATES ARMY
    Inventors: Alan S. Cross, Apurba K. Bhattacharjee, Wendell D. Zollinger, Steven M. Opal
  • Detoxified Endotoxin Vaccine and Adjuvant and Uses thereof
    Publication number: 20090220522
    Abstract: The present invention describes a detoxified Gram negative J5 core lipopolysaccharide/group B meningococcal outer membrane protein complex vaccine given in conjunction with CpG 7909 adjuvant. This vaccine composition can be used for either active or passive immunization of mammals for the prevention or treatment of sepsis and infection with Gram negative bacteria. The addition of CpG to the vaccine was shown to markedly increase the antibody response in mice. Furthermore, the ability of the endotoxin vaccine in protecting against Gram-negative bacteria such as Francisella tularensis in vivo is also demonstrated herein.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 3, 2009
    Inventors: Alan S. Cross, Apurba K. Bhattacharjee, Wendell D. Zollinger, Steven M. Opal