Abstract: Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided.

Abstract: Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction andior osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided. Methods of synthesizing OXY133-statin conjugates that have low production costs are provided.

Abstract: Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided.

Abstract: Oxysterol-statin compounds and methods of synthesizing the same are provided for use in promoting osteogenesis, osteoinduction and/or osteoconduction. Methods of synthesizing in a single container OXY133-statin compounds having high yields and improved process safety are also provided. Methods for synthesizing OXY133-statin compounds that are stereoselective are also provided.

Abstract: The present invention generally relates to a method of using a matrix as a barrier for unwanted cell attachment and bone formation in unwanted areas of the human body during implant procedures. More specifically, a growth-inhibiting matrix may be used to prevent migration of osteo-inductive agents or bone tissue from an intervertebral disc space through the outer bands of annulus fibrosis that abuts the spinal tissue, canal, and other surrounding areas.

Abstract: A minimal access method for mammalian vertebrae interbody fusion without the employment of an interbody device is described which comprises injecting a porous CaPC into an anterior portion of a disc space, and injecting an effective amount of fast-setting non-porous CaPC into an anterior portion of the disc space to rapidly produce a strong and stable interbody fusion without the employment of an interbody device. Methods are further described wherein at least one of the CaPCs comprises an effective amount of at least one osteoinductive protein. A minimal access method for vertebroplasty is described which comprises injecting an effective amount of a viscous non-porous CaPC into a vertebrae fracture channel to provide rapid stabilization and strength, and injecting a porous CaPC into trabecular bone space adjacent to the vertebrae fracture channel. Kits which relate to the methods of the present invention are described as well.

Abstract: The present invention generally relates to a method of using a matrix as a barrier for unwanted cell attachment and bone formation in unwanted areas of the human body during implant procedures. More specifically, a growth-inhibiting matrix may be used to prevent migration of osteo-inductive agents or bone tissue from an intervertebral disc space through the outer bands of annulus fibrosis that abuts the spinal tissue, canal, and other surrounding areas.

Abstract: The present invention generally relates to a method of using a matrix as a barrier for unwanted cell attachment and bone formation in unwanted areas of the human body during implant procedures. More specifically, a growth-inhibiting matrix may be used to prevent migration of osteo-inductive agents or bone tissue from an intervertebral disc space through the outer bands of annulus fibrosis that abuts the spinal tissue, canal, and other surrounding areas.

Abstract: A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

Abstract: A spinous process clamp employs a pair of elongate plates that are positioned on either side of the spinous processes of vertebrae that are to be fused. The plates are joined by fasteners, preferably bolts and nuts. The plates include a recess on the bone facing side of the plate for retaining a bone growth promoting substance. When the bolts and nuts are tightened, the spinous processes are clamped between the plates, thereby pressing the bone growth promoting substance against the bone and encouraging bone growth across the vertebrae fixed by the plates.

Abstract: The present invention generally relates to a method of using a matrix as a barrier for unwanted cell attachment and bone formation in unwanted areas of the human body during implant procedures. More specifically, a growth-inhibiting matrix may be used to prevent migration of osteo-inductive agents or bone tissue from an intervertebral disc space through the outer bands of annulus fibrosis that abuts the spinal tissue, canal, and other surrounding areas.

Abstract: An osteochondral device is provided comprising an implant having a growth factor concentration gradient. The implant can be porous with a higher concentration of growth factors dispersed in the portion of the implant where new bone tissue is needed and a lower concentration of growth factors dispersed in the portion of the implant where new cartilage tissue is needed.

Abstract: A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

Abstract: A minimal access method for mammalian vertebrae interbody fusion without the employment of an interbody device is described which comprises injecting a porous CaPC into an anterior portion of a disc space, and injecting an effective amount of fast-setting non-porous CaPC into an anterior portion of the disc space to rapidly produce a strong and stable interbody fusion without the employment of an interbody device. Methods are further described wherein at least one of the CaPCs comprises an effective amount of at least one osteoinductive protein. A minimal access method for vertebroplasty is described which comprises injecting an effective amount of a viscous non-porous CaPC into a vertebrae fracture channel to provide rapid stabilization and strength, and injecting a porous CaPC into trabecular bone space adjacent to the vertebrae fracture channel. Kits which relate to the methods of the present invention are described as well.