Patents by Inventor Steven M. Simmons

Steven M. Simmons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10889652
    Abstract: Provided are ROR1 binding molecules, including anti-ROR1 antibodies, including antibody fragments such as variable heavy chain (VH) regions, single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). In some embodiments, the antibodies specifically bind to ROR1. Among the antibodies are human antibodies, including those that compete for binding to ROR1 with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: January 12, 2021
    Assignee: Juno Therapeutics, Inc.
    Inventors: Yan Chen, Steven M. Shamah, Csaba Pazmany, Jui Dutta-Simmons
  • Publication number: 20200392236
    Abstract: Provided herein are BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments, and chimeric receptors comprising the anti-BCMA binding molecules such as chimeric antigen receptors (CARs). In some embodiments, the anti-BCMA antibodies or antigen-binding fragments thereof specifically bind to BCMA-1. Among the anti-BCMA antibodies are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs or BCMA-binding molecules and uses thereof such as in adoptive cell therapy.
    Type: Application
    Filed: November 1, 2018
    Publication date: December 17, 2020
    Applicant: Juno Therapeutics, Inc.
    Inventors: Blythe D. SATHER, Steven M. SHAMAH, Yan CHEN, Rebecca WU, Collin HAUSKINS, Csaba PAZMANY, Jui DUTTA-SIMMONS, Kimberly HARRINGTON
  • Publication number: 20200172630
    Abstract: Provided are CD19 binding molecules, including anti-CD19 antibodies, including antibody fragments such as single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). Among the antibodies are human antibodies, including those that compete for binding to CD19 with reference antibodies, such as murine antibodies. In some embodiments, the antibodies display similar functional properties to the reference antibodies, such as comparable binding affinities and/or competitive inhibition properties. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.
    Type: Application
    Filed: December 2, 2019
    Publication date: June 4, 2020
    Applicant: Juno Therapeutics, Inc.
    Inventors: Yan CHEN, Steven M. SHAMAH, Csaba PAZMANY, Jui DUTTA-SIMMONS
  • Patent number: 10618926
    Abstract: The present invention is directed to process for making Compounds of Formula (II): (II), and salts thereof, wherein B, X, R2, R3, R4 R7, R8 and R9 are defined herein.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 14, 2020
    Assignee: Merck Sharp & Dohme
    Inventors: Steven M. Silverman, Bryon Ladd Simmons, Zhuqing Liu, Jing Liao, Artis Klapars, Kevin R. Campos, Ana Inés Bellomo Peraza
  • Publication number: 20200109134
    Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 9, 2020
    Inventors: Ke Chen, Joerg Deerberg, Dong Lin, Michael Dummeldinger, Bahar Inankur, Sergei Kolotuchin, Jun Li, Amanda J. Rogers, Victor W. Rosso, Eric M. Simmons, Maxime C.D. Soumeillant, Daniel S. Treitler, Jianji Wang, Bin Zheng, Michael J. Smith, Neil A. Strotman, Steven Tymonko, Tamas Benkovics
  • Patent number: 10533055
    Abstract: Provided are CD19 binding molecules, including anti-CD19 antibodies, including antibody fragments such as single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). Among the antibodies are human antibodies, including those that compete for binding to CD19 with reference antibodies, such as murine antibodies. In some embodiments, the antibodies display similar functional properties to the reference antibodies, such as comparable binding affinities and/or competitive inhibition properties. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: January 14, 2020
    Assignee: JUNO THERAPEUTICS, INC.
    Inventors: Yan Chen, Steven M. Shamah, Csaba Pazmany, Jui Dutta-Simmons
  • Patent number: 10394106
    Abstract: An integrated underwater imaging device includes a housing with a transparent optical port, a camera and one or more LED light sources with optically coupled to light pipes within the housing. The optical port includes light mitigation features to reduce internal light contamination from the LED light sources on the imager of the camera.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 27, 2019
    Assignee: DEEPSEA POWER & LIGHT LLC
    Inventors: Mark S. Olsson, Eric M. Chapman, Aaron J. Steiner, Jon E. Simmons, Steven C. Tietsworth
  • Patent number: 9942365
    Abstract: Separating and isolating multiple network stacks in a network element may enable a network element to simultaneously operate within multiple forwarding planes respectively corresponding to the multiple network stacks. In addition to the network stack, other protocols and routing tools may also be instantiated for each desired forwarding plane. The different instantiations of the network stacks may be executed in parallel in respective memory spaces that are distinct and separate. In this manner, each forwarding plane may operate independently on the network element from other forwarding planes.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: April 10, 2018
    Assignee: Fujitsu Limited
    Inventors: Albert V. Smith, Nasir Iqbal Amanullah, Bradford J. Dobson, Tintooda Nakakes, Steven M. Simmons
  • Publication number: 20150271304
    Abstract: Separating and isolating multiple network stacks in a network element may enable a network element to simultaneously operate within multiple forwarding planes respectively corresponding to the multiple network stacks. In addition to the network stack, other protocols and routing tools may also be instantiated for each desired forwarding plane. The different instantiations of the network stacks may be executed in parallel in respective memory spaces that are distinct and separate. In this manner, each forwarding plane may operate independently on the network element from other forwarding planes.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 24, 2015
    Inventors: Albert V. Smith, Nasir Iqbal Amanullah, Bradford J. Dobson, Tintooda Nakakes, Steven M. Simmons
  • Patent number: 8493872
    Abstract: A method and system for determining a path between nodes in a network are disclosed. In accordance with an embodiment of the present disclosure, a system for determining a path between nodes in a network comprises a destination node and a link aggregation group (LAG) that includes a first link and a second link. The system further comprises a source node communicatively coupled to the destination node by the LAG where the source node, the LAG and the destination node form a path. The source node is operable to determine a link availability status for each of the first and second links using a layer-2 protection scheme. The source node is further operable to monitor the path for connectivity based on the link availability status using a layer-3 protection scheme.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 23, 2013
    Assignee: Fujitsu Limited
    Inventors: Albert Smith, Nimer Yaseen, Zanjun Lu, Joseph K. Nguyen, Stephen Graham, Sushanth Vallath, Steven M. Simmons
  • Patent number: 8462636
    Abstract: According to one embodiment, a network element may include one or more network interfaces and a master control unit communicatively coupled to the one or more network interfaces. The one or more network interfaces may include in the aggregate, a plurality of physical ports configured as member ports of a link aggregation group. The master control unit may be configured to maintain a routing table, such routing table including information regarding which of the plurality of physical ports of the link aggregation group is designated as an active port for management traffic egressing via the link aggregation group, wherein the active port carries a communication channel for the management traffic segregated from carrier traffic, and communicate the routing table to each of the one or more network interfaces.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: June 11, 2013
    Assignee: Fujitsu Limited
    Inventors: Steven M. Simmons, Albert Smith
  • Publication number: 20110194562
    Abstract: According to one embodiment, a network element may include one or more network interfaces and a master control unit communicatively coupled to the one or more network interfaces. The one or more network interfaces may include in the aggregate, a plurality of physical ports configured as member ports of a link aggregation group. The master control unit may be configured to maintain a routing table, such routing table including information regarding which of the plurality of physical ports of the link aggregation group is designated as an active port for management traffic egressing via the link aggregation group, wherein the active port carries a communication channel for the management traffic segregated from carrier traffic, and communicate the routing table to each of the one or more network interfaces.
    Type: Application
    Filed: February 10, 2010
    Publication date: August 11, 2011
    Applicant: FUJITSU NETWORK COMMUNICATIONS, INC.
    Inventors: Steven M. Simmons, Albert Smith
  • Publication number: 20110038267
    Abstract: A method and system for determining a path between nodes in a network are disclosed. In accordance with an embodiment of the present disclosure, a system for determining a path between nodes in a network comprises a destination node and a link aggregation group (LAG) that includes a first link and a second link. The system further comprises a source node communicatively coupled to the destination node by the LAG where the source node, the LAG and the destination node form a path. The source node is operable to determine a link availability status for each of the first and second links using a layer-2 protection scheme. The source node is further operable to monitor the path for connectivity based on the link availability status using a layer-3 protection scheme.
    Type: Application
    Filed: March 26, 2010
    Publication date: February 17, 2011
    Applicant: FUJITSU NETWORK COMMUNICATIONS, INC.
    Inventors: Albert Smith, Nimer Yaseen, Zanjun Lu, Joseph K. Nguyen, Stephen Graham, Sushanth Vallath, Steven M. Simmons
  • Patent number: 5956512
    Abstract: A debugger is used in an environment of optimized compiling to track both user-defined and synthesized variables so that the values of these variables at selected programmer counter addresses can be either determined or set. The tracking is primarily accomplished by the generation of various interrelated tables including a Type Scope Table, a Name Space Table, an Expression Table, a Location Range Tab and a Variable Table. These tables define the existence of variable at defined program counter ranges and provide the algebraic definitions for the synthesized variables. A programmer can efficiently debug a program produced with optimized compiling through the operations of determining variable values and setting variable values.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: September 21, 1999
    Assignee: Hewlett-Packard Co.
    Inventors: Steven M. Simmons, Gary S. Brooks
  • Patent number: 5371747
    Abstract: Debugging of computer programs is necessary for the development of the programs as well as for maintaining the operation of the programs. Symbolic debugging requires the ability to relate the current position in the object code program to the corresponding position in the source code. In the absence of compiler optimization, correlating the source and object code elements is a straightforward procedure. However, when the object code has been optimized, the relation between the source code constructs and object code instructions can become convoluted and complex. A correlation technique for optimized code is disclosed which maps the source constructs (source units) through each of the optimization operations by use of compilation nodes and associated source units to build a table which relates ranges of object instructions to the source units which produced the object instructions.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: December 6, 1994
    Assignee: Convex Computer Corporation
    Inventors: Gary S. Brooks, Steven M. Simmons