Patents by Inventor Steven M. TAFFET

Steven M. TAFFET has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS ACTING AS PEPTIDE GAP JUNCTION MODULATORS, AND USES THEREOF
    Publication number: 20120264693
    Abstract: Compounds capable of modulating intracellular gap junctional communication, as well as their use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC) 1 are disclosed.
    Type: Application
    Filed: June 11, 2010
    Publication date: October 18, 2012
    Applicants: Zealand Pharma A/S, The Regents of the University of Michigan, The Research Foundation of State Univesity of New York
    Inventors: Mario Delmar, Steven M. Taffet, Wanda Coombs, Vandana Verma, Bjarne Due Larsen
  • PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    Publication number: 20120101255
    Abstract: The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.
    Type: Application
    Filed: October 24, 2011
    Publication date: April 26, 2012
    Applicants: Zealand Pharma A/S, The Research Foundation of State University of New York
    Inventors: Mario Delmar, Steven M. Taffet, Bjarne Due Larsen
  • PEPTIDE GAP JUNCTION MODULATORS
    Publication number: 20100298225
    Abstract: Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).
    Type: Application
    Filed: July 14, 2008
    Publication date: November 25, 2010
    Inventors: Bjarne Due Larsen, Mario Delmar, Steven M. Taffet, Wanda Coombs
  • PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    Publication number: 20090075291
    Abstract: The present invention relates to proteins and polypeptides that (i) have the formula A-[Wm-A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A-An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number
    Type: Application
    Filed: July 14, 2008
    Publication date: March 19, 2009
    Applicants: The Research Foundation of State University of New York, Zealand Pharma A/S
    Inventors: Mario DELMAR, Steven M. TAFFET, Bjarne Due LARSEN