Patents by Inventor Steven M. Toler

Steven M. Toler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating bladder disorders
    Patent number: 8901177
    Abstract: The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of bladder disorders, including overactive bladder.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 2, 2014
    Assignee: Targacept, Inc.
    Inventors: Merouane Bencherif, Steven M. Toler
  • TREATMENT WTH ALPHAT SELECTIVE LIGANDS
    Publication number: 20140234270
    Abstract: The present invention includes methods, uses, and selective alpha7 nAChR ligands for treating or preventing disease and disorders in which stimulation of neurogenesis is ameliorative; namely, wherein the recruitment of neurogenesis is therapeutic.
    Type: Application
    Filed: April 23, 2014
    Publication date: August 21, 2014
    Applicant: TARGACEPT, INC.
    Inventors: Merouane Bencherif, Kristen Jordan, Terry Hauser, Steven M. Toler, Sharon Rae Letchworth, David C. Kombo
  • Combination therapy for the management of hypertension
    Patent number: 8569381
    Abstract: The present invention includes a combination comprising: a) mecamylamine; and b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, or a combination thereof.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: October 29, 2013
    Assignee: Targacept, Inc.
    Inventors: Steven M. Toler, David A. Hosford
  • METHOD OF TREATING BLADDER DISORDERS
    Publication number: 20130253067
    Abstract: The present invention relates to dexmecamylamine and the use of dexmecamylamine, substantially free of exo-R-mecamylamine, in the treatment of bladder disorders, including overactive bladder.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 26, 2013
    Applicant: TARGACEPT, INC.
    Inventors: Merouane Bencherif, Steven M. Toler
  • ARYLVINYLAZACYCLOALKANE COMPOUNDS FOR CONSTIPATION
    Publication number: 20130237550
    Abstract: The present invention relates to method of treating constipation and enhancing colonic motility by administration of 5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 12, 2013
    Applicant: TARGACEPT, INC.
    Inventors: Steven M. Toler, David Hosford, Patrick M. Lippiello, Geoffrey Charles Dunbar, William Scott Caldwell, Parviz Hamedani, Merouane Bencherif
  • EXO-S-MECAMYLAMINE METHOD, USE, AND COMPOUND FOR TREATMENT
    Publication number: 20120190752
    Abstract: The present invention relates to exo-S-mecamylamine and the use of exo-S-mecamylamine in medical treatments.
    Type: Application
    Filed: July 12, 2010
    Publication date: July 26, 2012
    Applicant: Targacept Inc.
    Inventors: Geoffrey C. Dunbar, Jessica Beaver, Steven M. Toler
  • COMBINATION THERAPY FOR THE MANAGEMENT OF HYPERTENSION
    Publication number: 20120115917
    Abstract: The present invention includes a combination comprising: a) mecamylamine; and b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, or a combination thereof.
    Type: Application
    Filed: May 22, 2009
    Publication date: May 10, 2012
    Applicant: Targacept, Inc.
    Inventors: Steven M. Toler, David A. Hosford
  • TREATMENT WITH ALPHA7 SELECTIVE LIGANDS
    Publication number: 20110262407
    Abstract: The present invention includes methods, uses, and selective alpha7 nAChR ligands for treating or preventing disease and disorders in which stimulation of neurogenesis is ameliorative; namely, wherein the recruitment of neurogenesis is therapeutic.
    Type: Application
    Filed: November 9, 2009
    Publication date: October 27, 2011
    Applicant: Targacept, Inc.
    Inventors: Merouane Bencherif, Kristen Jordan, Terry Hauser, Steven M. Toler, Sharon Rae Letchworth, David C. Kombo
  • METHODS FOR PREVENTING THE DEVELOPMENT OF RETINOPATHY BY THE ORAL ADMINISTRATION OF NNR LIGANDS
    Publication number: 20110098312
    Abstract: Method and compositions for delaying the onset or progression of retinopathy, including administering at least one neuronal nicotinic ligand are disclosed.
    Type: Application
    Filed: May 11, 2009
    Publication date: April 28, 2011
    Applicant: Targacept ,Inc
    Inventors: Merouane Bencherif, Scott N. Cullison, Patrick M. Lippiello, Steven M. Toler