Abstract: Data analytics systems and methods are disclosed herein. A parser can parse reference data from various data sources to store in a data structure. An uploader can receive study data designated by a researcher and store the study data in the data structure. A matcher can compare analyte nameset data in the study data with analyte nameset data from the reference data to generate one or more links each correlating an instance of an analyte in the study data with an instance of that analyte in the reference data. Library overlays each include one or more modules to access reference data to generate organized associations of reference data. A calculation engine can receive a selection of one or more library overlay(s) and manipulate the reference data and study data according to the organized associations of the selected library overlay(s) to generate configured data stored in a collection of data caches for presentation to a researcher via a user interface.

Abstract: Data analytics systems and methods are disclosed herein. A parser can parse reference data from various data sources to store in a data structure. An uploader can receive study data designated by a researcher and store the study data in the data structure. A matcher can compare analyte nameset data in the study data with analyte nameset data from the reference data to generate one or more links each correlating an instance of an analyte in the study data with an instance of that analyte in the reference data. Library overlays each include one or more modules to access reference data to generate organized associations of reference data. A calculation engine can receive a selection of one or more library overlay(s) and manipulate the reference data and study data according to the organized associations of the selected library overlay(s) to generate configured data stored in a collection of data caches for presentation to a researcher via a user interface.

Abstract: Data analytics systems and methods are disclosed herein. A parser can parse reference data from various data sources to store in a data structure. An uploader can receive study data designated by a researcher and store the study data in the data structure. A matcher can compare analyte nameset data in the study data with analyte nameset data from the reference data to generate one or more links each correlating an instance of an analyte in the study data with an instance of that analyte in the reference data. Library overlays each include one or more modules to access reference data to generate organized associations of reference data. A calculation engine can receive a selection of one or more library overlay(s) and manipulate the reference data and study data according to the organized associations of the selected library overlay(s) to generate configured data stored in a collection of data caches for presentation to a researcher via a user interface.

Abstract: A method of assessing the level of triglycerides in the liver of a subject comprises determining the amount of a first lipid metabolite in a sample from the subject. The sample can be blood, plasma, serum, isolated lipoprotein fraction, saliva, urine, lymph fluid, bile, or cerebrospinal fluid. The first lipid metabolite is a fatty acid present in a lipid class. The lipid class is selected from the group consisting of free fatty acids, total fatty acids (TL), triglycerides (TG), cholesterol esters (CE), phosphatidylcholines (PC), and phosphatidylethanolamines (PE).

Abstract: Data analytics systems and methods are disclosed herein. A parser can parse reference data from various data sources to store in a data structure. An uploader can receive study data designated by a researcher and store the study data in the data structure. A matcher can compare analyte nameset data in the study data with analyte nameset data from the reference data to generate one or more links each correlating an instance of an analyte in the study data with an instance of that analyte in the reference data. Library overlays each include one or more modules to access reference data to generate organized associations of reference data. A calculation engine can receive a selection of one or more library overlay(s) and manipulate the reference data and study data according to the organized associations of the selected library overlay(s) to generate configured data stored in a collection of data caches for presentation to a researcher via a user interface.

Abstract: The invention relates to biomarkers associated with Diabetes, including protein and lipid metabolite biomarkers, methods of using the biomarkers to determine the risk that an individual will develop Diabetes, and methods of screening a population to identify persons at risk for developing Diabetes and other pre-diabetic conditions.

Abstract: Biomarkers of NASH, NAFLD, and fibrosis and methods for diagnosis (or aiding in the diagnosis) of NAFLD, NASH and/or fibrosis are described herein. Additionally, methods of distinguishing between NAFLD and NASH, methods of classifying the stage of fibrosis, methods of determining the severity of liver disease, methods of determining the severity of liver disease or fibrosis, and methods of monitoring progression/regression of NASH, NAFLD, and/or fibrosis are described herein.

Abstract: Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.

Abstract: A video source associated with an information ticker may be captured, and the associated information ticker may be broadcast and displayed below or near an array of simultaneously broadcast video sources being broadcast in a mosaic of video sources. The displayed information ticker may be broadcast in association with one or more of a plurality of simultaneously broadcast video sources in the mosaic of video sources.

Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.

Abstract: Novel methods for assessing the level of triglycerides in the liver of a subject are described, comprising determining the amount of a lipid metabolite in a sample from a body fluid of the subject. The methods may be used, for example, in diagnosing and monitoring liver disorders such as steatosis, NAFLD and NASH.

Abstract: Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the response to a drug which alters a diabetic condition.

Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.

Abstract: The present invention provides methods for assessing contribution of one or more pathways to the biosynthesis of a metabolite, e.g., a lipid using the levels of the product made and the metabolite precursors for each pathway.

Abstract: A video source associated with an information ticker may be captured, and the associated information ticker may be broadcast and displayed below or near an array of simultaneously broadcast video sources being broadcast in a mosaic of video sources. The displayed information ticker may be broadcast in association with one or more of a plurality of simultaneously broadcast video sources in the mosaic of video sources.

Abstract: This disclosure provides methods for the creation of a quantitative database of metabolites, particularly lipid metabolites, using chromatographic technology; methods for assembling that information into a visual format for interpretation, and methods of this information to identify and understand metabolome-wide effects, for instance those effects influenced by pharmaceuticals, genes, toxins, diet or the environment. Also provided are metabolite databases, such as lipid metabolite databases, that are stored on a computer readable medium, which include quantitative measurements of a plurality of metabolites.

Abstract: The present invention provides metabolic markers and targets, especially PEMT activity and metabolic markers and components associated therewith useful for diagnosing and treating various disease conditions.