Patents by Inventor Steven M. Wishnies

Steven M. Wishnies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8525104
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: September 3, 2013
    Assignee: New York University
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnies
  • Publication number: 20110062320
    Abstract: The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
    Type: Application
    Filed: April 27, 2010
    Publication date: March 17, 2011
    Inventors: Paul Pevsner, Frederick Naftolin, Douglas C. Miller, Dean Hillman, Brian K. Stall, Steven M. Wishnies