Abstract: A method of treating a bradykinin-mediated disease, wherein the method includes administering to a subject in need thereof an effective amount of a modified ?1 antitrypsin including a reactive center loop (RCL), wherein the residues P4-P1 of the RCL are selected from the group consisting of SMTR (SEQ ID NO: 12), SEAR (SEQ ID NO: 18), SMDR (SEQ ID NO: 23), SLGR (SEQ ID NO: 24), SKGR (SEQ ID NO: 25) and SMHR (SEQ ID NO: 27), wherein the modified al antitrypsin demonstrates increased inhibition of plasma kallikrein (PK) as compared to the corresponding unmodified ?1 antitrypsin, and wherein the modified ?1-antitrypsin more strongly inhibits PK than the modified ?1 antitrypsin inhibits either one of thrombin or APC.

Abstract: An optical accelerometer includes means for changing the length of at least one optical fiber in response to acceleration functionally coupled to the at least one optical fiber. The fiber and the means for changing length are enclosed in a pressure compensated housing. The housing is filled with a substantially incompressible fluid or gel.

Abstract: An optical accelerometer includes a beam and at least one optical fiber affixed to one side of the beam such that deflection of the beam changes a length of the optical fiber. Means for sensing the change in length of the optical fiber is functionally coupled to the at least one fiber. A seismic sensor system includes at least two accelerometers, oriented such that their sensitive axes are at least partially aligned along mutually orthogonal directions. Each accelerometer includes a beam, and at least one optical fiber affixed to one side of the beam such that deflection of the beam changes a length of the at least one optical fiber. Means for sensing the change in length of the optical fiber is functionally coupled to at least one fiber of each accelerometer.

Abstract: An optical fiber sensor array is disclosed which includes a first sensor fiber and a first reference fiber coupled at one end thereof to one side of a first optical coupling. A first wavelength selective reflector is coupled to the other end of each of the first sensor fiber and the first reference fiber. A second sensor fiber is coupled at one end to one side of a second optical coupling. The other side of the second optical coupling is coupled to an opposite side of one of the first wavelength selective reflectors coupled on one side to the first sensor fiber and the first reference fiber. The array also includes a second wavelength selective reflector coupled to the other end of each of the second sensor fiber and the second reference fiber. The second wavelength selective reflectors are operative at a wavelength different from an operative wavelength of the first wavelength selective reflectors.

Abstract: A method for attaching seismic sensors in a seismic cable that includes a strength member inside a cable jacket with a fiber tube wound around the strength member and a sensor station base attached around the cable wherein the jacket is removed, at least one fiber tube is extracted and a seismic sensor is attached to the fiber tube.

Abstract: A method and system for interrogating a seismic sensor in a seismic cable having modular sensing stations spaced along the seismic cable and a connection module head end of the sensor sections, that includes dropping, at the connection modules, a wavelength of light from an input bus telemetry fiber that includes multiple wavelengths of light, distributing the dropped wavelength of light to the seismic sensor, returning the dropped wavelength from the seismic sensor to a return telemetry fiber, remultiplexing the dropped wavelength of light onto the return bus telemetry, and amplifying, in the seismic cable, the returned dropped wavelength.