Patents by Inventor Steven Mark Dunn

Steven Mark Dunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF IMPROVING T CELL RECEPTORS
    Publication number: 20090054257
    Abstract: A method of increasing the affinity and/or decreasing the off-rate of a given TCR specific for a given target pMHC, comprising creating a plurality of TCRs having an ? chain CDR2 sequence and/or a ? chain CDR2 sequence different from the corresponding CDR2 sequence(s) of the given TCR but having the same ? and ? CDR1 and CDR3 sequences as the given TCR, determining the affinity and/or off-rate of members of said plurality of TCRs for the target pMHC, and selecting one or more members having at least a 10-fold greater affinity for the target pMHC than the given TCR and/or a 10-fold slower off-rate for the target pMHC than the given TCR.
    Type: Application
    Filed: October 7, 2008
    Publication date: February 26, 2009
    Applicant: MEDIGENE LIMITED
    Inventors: STEVEN MARK DUNN, YI LI, JONATHAN MICHAEL BOULTER, LUCY BOULTER