Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: A system for fabricating a dental restoration to restore a tooth at a restoration site in a dentition of a patient is disclosed. The dentition includes a restoration dental arch and an opposing dental arch. The restoration dental arch includes the restoration site and the opposing dental arch is opposite the restoration dental arch. The system includes an impression apparatus, a motion capture apparatus, an interface apparatus, and a restoration design system. The impression apparatus is configured to capture an impression of the dentition of the patient. The motion capture apparatus is configured to capture a plurality of location data points that represent the locations of the opposing dental arch relative to the restoration dental arch. The interference model generation system is configured to generate an interference model for the restoration site. The restoration design system is for designing a restoration using the interference model.

Abstract: An HME device has a housing (10) containing an HME element (25). The device has a first gas-flow passage through the device via the HME element (25) and a second gas-flow passage that by-passes the HME element. Flow is switched between the first or second flow passage by a pivoted shutter (30) that can be displaced by a rotatable knob (32).

Abstract: According to certain aspects, a computer-implemented method for operating an autonomous or semi-autonomous vehicle may be provided. With the customer's permission, an identity of a vehicle operator may be identified and a vehicle operator profile may be retrieved. Operating data regarding autonomous operation features operating the vehicle may be received from vehicle-mounted sensors. When a request to disable an autonomous feature is received, a risk level for the autonomous feature is determined and compared with a driver behavior setting for the autonomous feature stored in the vehicle operator profile. Based upon the risk level comparison, the autonomous vehicle retains control of vehicle or the autonomous feature is disengaged depending upon which is the safer driver—the autonomous vehicle or the vehicle human occupant. As a result, unsafe disengagement of self-driving functionality for autonomous vehicles may be alleviated.

Abstract: The technology disclosed herein enables detection of domain hijacking when a DNS resolver is performing a DNS lookup. In a particular embodiment, a method provides, in response to a request to resolve a network address corresponding to a domain name, determining that a nameserver for the domain name is suspect based on satisfaction of nameserver criteria associated with the domain name. The method further includes preventing the nameserver from being used to resolve the request in response to determining that the nameserver is suspect.

Abstract: In a computer-implemented method, alert responsiveness data indicating how responsive a driver is to one or more types of vehicle alerts is received. The method also includes generating or modifying a driver profile associated with the driver, the driver profile including alert responsiveness profile information based upon the alert responsiveness data, and identifying, based at least upon the generated or modified driver profile, a suggested vehicle type. Identifying the suggested vehicle type includes determining that the generated or modified driver profile meets a set of one or more matching criteria associated with the suggested vehicle type at least in part by determining that the alert responsiveness profile information meets one or more criteria indicative of reliability of the suggested vehicle type. The method also includes causing an indication of the suggested vehicle type to be displayed to a user.

Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: A client application is specified by a target tenant and represented in an OAuth provider, along with a corresponding secret. A source tenant consents to permissions to be executed by the client application on a resource of the source tenant. A target service uses the secret to obtain an access token from an authorization server coupled to the source tenant and uses the access token to obtain access, specified by the permissions, to the resource served by a source service acting on behalf of the source tenant.

Abstract: A method for delivering a plurality of packages is described. The method includes obtaining, via a processor, information associated with a delivery plan of the plurality of packages from at least one memory. Based on the information, the method includes determining, via the processor, a current location, and a destination location of a target container. In response to the determination, the method includes determining, via the processor, a movement plan to move the target container to the destination location. Based on the movement plan, the method includes activating, via the processor, a first set of motorized tiles to move the target container to the destination location. The method further includes receiving, via the processor, an updated movement plan from a server plan when a preset condition is met. Based on the updated movement plan, the method includes activating, via the processor, a second set of motorized tiles.

Abstract: Prevention of voice misappropriation in voice interaction/response systems. The system relies on telemetry data, including thermal data of components to determine whether a received voice command was made by actual voice. If the voice command is determined to have been made by an actual voice, a response to the command is generated and transmitted, otherwise if the voice command is determined to have likely not been made by an actual voice (e.g., artificial means replicating a voice, such as a laser or the like), no response to the command is transmitted or action taken with respect to the command.

Abstract: In one example, a timing control system for a faucet for dispensing water includes a valve sensor, a timer, and a light. The valve sensor is configured to detect operation of the faucet. The timer is configured to trigger a countdown in response to the operation of the faucet. The light is configured to illuminate the water of the faucet in at least one color in response to the countdown.

Abstract: Prevention of voice misappropriation in voice interaction/response systems. The system relies on telemetry data, including thermal data of components to determine whether a received voice command was made by actual voice. If the voice command is determined to have been made by an actual voice, a response to the command is generated and transmitted, otherwise if the voice command is determined to have likely not been made by an actual voice (e.g., artificial means replicating a voice, such as a laser or the like), no response to the command is transmitted or action taken with respect to the command.

Abstract: A system for placing a person in electrical continuity with the ground in order to reduce the buildup of electric charge on a person's body. The system of the present invention comprises a shoe with an attached shoe grounding device and a plurality of grounded mats. The shoe grounding device is attached to the shoe in a manner that puts the interior surface of the body of the shoe in electrical continuity with the heel of the shoe. The heel of the shoe can be placed in electrical continuity with the ground by placing the heel of the shoe on top of any of the plurality of grounded mats, which are connected to the ground by a grounding wire. The system as a whole allows a person using the system to place themselves in electrical continuity with the ground.

Abstract: One example discloses a near-field interface device, including: a near-field antenna; a physical port configured to be coupled to a computer; a controller coupled to the antenna and the physical port; wherein the controller is configured to translate a near-field signal received from the near-field antenna into an input command generated by a user; and wherein the controller is configured to transmit the input command to the computer through the physical port.

Abstract: A method comprising obtaining a desired storage criterion for each of a plurality of products, the desired storage criteria including at least one condition, the at least one condition including a product temperature range; based on the product temperature range setting for each product at least one alert temperature range; calculating a current temperature of each of the plurality of products located in a compartment at a current time; calculating future temperatures of each of the plurality of products at a plurality of future times based on the current temperatures and expected changes between the current time and the plurality of future times; and for each of the plurality of products raising an alert if the current or calculated future temperature exceeds the product temperature range for that product.

Abstract: A cannulated retrograde reamer that is adjustable to create tunnels of multiple different diameters. The cannulated retrograde reamer substantially reduces the risk of tunnel malposition and/or misalignment, and can be adjusted to create a range of tunnel diameters, thereby allowing inventory levels to be reduced for a surgical case.

Abstract: Embodiments of systems and methods as disclosed may provide a platform agnostic way to edit content within an enterprise. For example, a platform independent thin client editor may be provided such that this editor can be accessed by users at a variety of computing platforms across the distributed computer network of an enterprise, regardless of the platform from which the thin client editor is being accessed. Moreover, certain embodiments may provide a role based mechanism for controlling the editing of content. Embodiments of such a role based mechanism may allow one editor of a content item to designate a role associated with the content item so that only users associated with that role may be allowed to edit the content item or portion of the content item.

Abstract: A system and computerized method for rendering content in a mixed reality installations is provided. The method includes identifying a mixed reality space containing a user position of a user, determining a user gaze direction of the user via a user device, identifying a view volume intersecting the user gaze direction while the user is in the mixed reality space, determining that the view volume is associated with the mixed reality space, and selecting a content entity associated with the view volume to render to the user via the user device.

Abstract: A digital communication method, comprising: providing a digital packet radio transceiver which communicates through an antenna array, defining a directional pattern with distinct spatial communication channels using a plurality of frequency channels; detecting channel conditions based on a feedback protocol between the digital packet radio transceiver and a remote digital packet radio system, selectively controlling the digital packet transceiver to transmit information responsive to the channel conditions; detecting another digital packet radio transceiver concurrently using the same frequency channels, and selectively controlling an interference with the other digital packet radio transceiver in dependence on information from the other digital packet radio transceiver, by one of deferring to transmissions by the other digital packet radio transceiver, and competing with transmissions by the other digital packet radio transceiver.

Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.