Patents by Inventor Steven Mathieu

Steven Mathieu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt form of a human histone methyltransferase EZH2 inhibitor
    Patent number: 9872862
    Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 23, 2018
    Assignees: Epizyme, Inc., Eisai R&D Management Co., Ltd.
    Inventors: Kevin Wayne Kuntz, Kuan-Chun Huang, Hyeong Wook Choi, Kristen Sanders, Steven Mathieu, Arani Chanda, Frances Fang
  • Synthetic route to 2?-deoxy-2?,2?-difluorotetrahydrouridines
    Patent number: 9834576
    Abstract: The present invention relates to methods and intermediates for synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine compounds.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: December 5, 2017
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hyeong-wook Choi, Steven Mathieu, Frank Fang, Bryan Matthew Lewis
  • STEREOCHEMICALLY DEFINED POLYPROPIONATES AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20170240560
    Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 24, 2017
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. FANG, Hyeong-Wook CHOI, Silvio CAMPAGNA, Steven MATHIEU
  • SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR
    Publication number: 20170143729
    Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
    Type: Application
    Filed: June 30, 2016
    Publication date: May 25, 2017
    Inventors: Kevin Wayne KUNTZ, Kuan-Chun HUANG, Hyeong Wook CHOI, Kristen SANDERS, Steven MATHIEU, Arani CHANDA, Frances FANG
  • HYDROCHLORIDE SALT FORM FOR EZH2 INHIBITION
    Publication number: 20160237068
    Abstract: Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.
    Type: Application
    Filed: October 15, 2014
    Publication date: August 18, 2016
    Inventors: Kevin W. KUNTZ, Hyeong-wook CHOI, Steven MATHIEU, Kristen SANDERS, Arani CHANDA
  • Synthetic Route to 2'-Deoxy-2',2'-Difluorotetrahydrouridines
    Publication number: 20160237107
    Abstract: The present invention relates to methods and intermediates for synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine compounds.
    Type: Application
    Filed: October 29, 2014
    Publication date: August 18, 2016
    Inventors: Hyeong-wook Choi, Steven Mathieu, Frank Fang, Bryan Matthew Lewis
  • Salt form of a human histone methyltransferase EZH2 inhibitor
    Patent number: 9394283
    Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: July 19, 2016
    Assignees: Epizyme, Inc., Eisai R&D Management Co., LTD.
    Inventors: Kevin Wayne Kuntz, Kuan-Chun Huang, Hyeong Wook Choi, Kristen Sanders, Steven Mathieu, Arani Chanda, Frances Fang
  • SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR
    Publication number: 20150065503
    Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 5, 2015
    Inventors: Kevin Wayne Kuntz, Kuan-chun Huang, Hyeong wook Choi, Kristen Sanders, Steven Mathieu, Arani Chanda, Frank Fang
  • Synthesis of beta-L-2'-deoxy nucleosides
    Publication number: 20050059632
    Abstract: An improved process for the preparation of 2?-modified nucleosides and 2?-deoxy-nucleosides, such as, ?-L-2?-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2?-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2?-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2?-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2?-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2?-deoxynucleosides in good yields.
    Type: Application
    Filed: June 30, 2004
    Publication date: March 17, 2005
    Inventors: Richard Storer, Adel Moussa, Jingyang Wang, Narayan Chaudhuri, Steven Mathieu, Alistair Stewart
  • Process for the production of 3'-nucleoside prodrugs
    Publication number: 20040181051
    Abstract: Provided is a single-step process for the selective 3′-acylation of a ribofuranosyl 2′ or 3′-branched nucleoside. These compounds are useful as antiviral agents, and in particular, can be used to treat Flaviviridae infections in a host in need thereof.
    Type: Application
    Filed: December 23, 2003
    Publication date: September 16, 2004
    Inventors: Richard Storer, Adel M. Moussa, Steven Mathieu