Abstract: Devices and methods are provided herein for monitoring tissue condition. A device as described herein may comprise a base layer configured to attach or encompass a portion of the subject's body in proximity to the target site; a plurality of light emitting diodes (LEDs) coupled to the base layer corresponding to one or more predetermined locations on the portion of the subject's body, wherein the plurality of LEDs is configured to emit light signals at the one or more predetermined locations penetrating beneath the skin of the subject to the target site; and a plurality of photodiodes configured to receive reflected light signals associated with the target site, wherein the reflected light signals are analyzed to determine a plurality of physiological parameters comprising at least volumetric blood flow through, at, or in proximity to the target site, and wherein the plurality of physiological parameters is used to monitor a state of the target site.