Patents by Inventor Steven Matthysse

Steven Matthysse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND SYSTEMS FOR DRUG SCREENING AND COMPUTATIONAL MODELING BASED ON BIOLOGICALLY REALISTIC NEURONS
    Publication number: 20110301856
    Abstract: A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test composition has the potential to be effective in treating the disorder.
    Type: Application
    Filed: May 6, 2011
    Publication date: December 8, 2011
    Applicant: MCLEAN HOSPITAL CORPORATION
    Inventors: Peter Siekmeier, Steven Matthysse
  • Methods and systems for drug screening and computational modeling based on biologically realistic neurons
    Patent number: 7945392
    Abstract: A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test composition has the potential to be effective in treating the disorder.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: May 17, 2011
    Assignee: McLean Hospital Corporation
    Inventors: Peter Siekmeier, Steven Matthysse
  • Methods and Systems for Drug Screening and Computational Modeling Based on Biologically Realistic Neurons
    Publication number: 20080027651
    Abstract: A method for screening a test composition for potential efficacy in treatment of a disorder includes a first computer model representative of a volume of disease-afflicted neural tissue comprising biologically realistic neurons exposed to the test composition; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is desired. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test composition has the potential to be effective in treating the disorder.
    Type: Application
    Filed: November 14, 2006
    Publication date: January 31, 2008
    Inventors: Peter Siekmeier, Steven Matthysse
  • Methods and systems for drug screening and computational modeling
    Publication number: 20060089824
    Abstract: A method for screening a test compound for potential efficacy in treatment of a disorder includes creating a first computer model representative of a volume of disease-afflicted neural tissue exposed to the test compound; and providing an initial excitation to the first computer model. Following a selected computation interval, a first outcome is determined. The first outcome indicates a response of the first computer model to the initial excitation and indicates whether the test compound has the potential to be effective in treating the disorder.
    Type: Application
    Filed: May 30, 2003
    Publication date: April 27, 2006
    Inventors: Peter Siekmeier, Steven Matthysse