Patents by Inventor Steven McCarroll

Steven McCarroll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for detection of somatic structural variants
    Patent number: 12131803
    Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: October 29, 2024
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Giulio Genovese, Po-Ru Loh, Steven McCarroll
  • CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF
    Publication number: 20220348590
    Abstract: The present disclosure describes compounds of the formula: (I), (II), (III), (IV), (V). The compounds described herein may be cyclooxygenase (COX) (e.g., cyclooxygenase 2 (COX2)) inhibitors. The compounds may be radiolabeled. The compounds (e.g., radiolabeled compounds) may be useful (e.g., as positron emission tomography (PET) imaging agents) for diagnosing a disease. The compounds may also be useful for treating or preventing a disease. The present disclosure also describes pharmaceutical compositions and kits including the compounds; and methods of using the compounds.
    Type: Application
    Filed: September 10, 2020
    Publication date: November 3, 2022
    Applicants: The Board Institute, Inc., The General Hospital Corporation, Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Florence Fevrier Wagner, Michel Weiwer, Arthur J. Campbell, Joshua R. Sacher, Antoine Bigot, Agathe Fayet, Besnik Bajrami, Jacob Hooker, Michael Placzek, Beth A. Stevens, Daniel Wilton, Steven McCarroll
  • Method for determination and identification of cell signatures and cell markers
    Patent number: 11225689
    Abstract: The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: January 18, 2022
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Karthik Shekhar, Sylvain Lapan, Irene Whitney, Evan Macosko, Steven McCarroll, Constance Cepko, Aviv Regev, Joshua Sanes
  • METHODS AND SYSTEMS FOR DETECTION OF SOMATIC STRUCTURAL VARIANTS
    Publication number: 20200303036
    Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: September 24, 2020
    Inventors: Giulio Genovese, Po-Ru Loh, Steven McCarroll
  • Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility
    Publication number: 20070172853
    Abstract: Disclosed herein are methods for predicting the immunocompatibility of two subjects that include determining the presence or absence of one or more deletion variants in the DNA sequence of a gene, where the deletion variant substantially prevents expression of the protein encoded by the gene.
    Type: Application
    Filed: December 4, 2006
    Publication date: July 26, 2007
    Applicant: The General Hospital Corporation
    Inventors: Steven McCarroll, David Altshuler