Patents by Inventor Steven McKnight

Steven McKnight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sprouty and SPRED protein biosensors
    Publication number: 20060148027
    Abstract: Sprouty/SPRED protein cysteine-rich domain (SCRD) modules comprising an iron:sulfer complex are used to sense electro/chemical signals.
    Type: Application
    Filed: January 5, 2006
    Publication date: July 6, 2006
    Inventors: Steven McKnight, Xinle Wu, Pia Vogel, Peter Alexander, Julian Peterson
  • Regulating PAS domain function with foreign PAS ligands
    Publication number: 20060051829
    Abstract: A functional surface binding specificity of a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is changed by (a) introducing into the hydrophobic core of the PAS domain a foreign ligand of the PAS domain; and (b) detecting a change in the functional surface binding specificity of the PAS domain.
    Type: Application
    Filed: October 11, 2005
    Publication date: March 9, 2006
    Inventors: Kevin Gardner, Carlos Amezcua, Paulus Erbel, Paul Card, Shannon Harper, Jared Rutter, Richard Bruick, Steven McKnight
  • Foreign PAS ligands regulate PAS domain function
    Publication number: 20050074846
    Abstract: Specific binding of a foreign core ligand to a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is determined by (a) detecting a first NMR spectrum of the PAS domain in the presence of a foreign ligand; and (b) comparing the first NMR spectrum with a second NMR spectrum of the PAS domain in the absence of the ligand to infer the presence the ligand specifically bound within the hydrophobic core of the PAS domain. A functional surface binding specificity of a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is changed by (a) introducing into the hydrophobic core of the PAS domain a foreign ligand of the PAS domain; and (b) detecting a change in the functional surface binding specificity of the PAS domain.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 7, 2005
    Inventors: Kevin Gardner, Carlos Amezcua, Paulus Erbel, Paul Card, Shannon Harper, Jared Rutter, Richard Bruick, Steven McKnight