Patents by Inventor Steven Metzger
Steven Metzger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11179541Abstract: The invention discloses methods and systems for modulation of the central nervous system and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations, the rhythmic and/or repetitive electrical activity generated spontaneously and in response to stimuli by neural tissue in the central nervous system. Various embodiments concern methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and for adjusting the treatment protocol to optimize the therapeutic effect of the stimulus or stimuli.Type: GrantFiled: April 1, 2020Date of Patent: November 23, 2021Assignee: Phoenix NeuroStim Therapeutics, LLCInventor: Steven Metzger
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Patent number: 10946165Abstract: Methods and apparatus for modulation of the central nervous system, and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations in the brain. Also described are methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and adjusting the treatment protocol to improve the therapeutic effect of the stimulus or stimuli.Type: GrantFiled: May 4, 2016Date of Patent: March 16, 2021Assignee: Phoenix NeuroStim Therapeutics, LLCInventor: Steven Metzger
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Publication number: 20200289785Abstract: The invention discloses methods and systems for modulation of the central nervous system and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations, the rhythmic and/or repetitive electrical activity generated spontaneously and in response to stimuli by neural tissue in the central nervous system. Various embodiments concern methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and for adjusting the treatment protocol to optimize the therapeutic effect of the stimulus or stimuli.Type: ApplicationFiled: April 1, 2020Publication date: September 17, 2020Applicant: Phoenix NeuroStim Therapeutics, LLCInventor: Steven Metzger
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Patent number: 10625042Abstract: The invention discloses methods and systems for modulation of the central nervous system and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations, the rhythmic and/or repetitive electrical activity generated spontaneously and in response to stimuli by neural tissue in the central nervous system. Various embodiments concern methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and for adjusting the treatment protocol to optimize the therapeutic effect of the stimulus or stimuli.Type: GrantFiled: November 4, 2014Date of Patent: April 21, 2020Assignee: Phoenix NeuroStim Therapeutics, LLCInventor: Steven Metzger
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Publication number: 20180221620Abstract: Methods and apparatus for modulation of the central nervous system, and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations in the brain. Also described are methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and adjusting the treatment protocol to improve the therapeutic effect of the stimulus or stimuli.Type: ApplicationFiled: May 4, 2016Publication date: August 9, 2018Inventor: Steven Metzger
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Publication number: 20160279380Abstract: The invention discloses methods and systems for modulation of the central nervous system and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations, the rhythmic and/or repetitive electrical activity generated spontaneously and in response to stimuli by neural tissue in the central nervous system. Various embodiments concern methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and for adjusting the treatment protocol to optimize the therapeutic effect of the stimulus or stimuli.Type: ApplicationFiled: November 4, 2014Publication date: September 29, 2016Inventor: Steven METZGER
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Publication number: 20070298513Abstract: This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that generated a sample image to a data processing apparatus.Type: ApplicationFiled: October 23, 2006Publication date: December 27, 2007Applicant: Accelr8 Technology CorporationInventors: Timothy Starzl, Scott Clark, Mary Vellequette, H. Hanlin, Steven Metzger
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Publication number: 20070037225Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: December 16, 2005Publication date: February 15, 2007Applicant: Accelr8 Technology CorporationInventors: Steven Metzger, David Howson, David Goldberg, Daniel Buttry
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Publication number: 20050147758Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: January 13, 2005Publication date: July 7, 2005Inventors: Guoqiang Mao, Steven Metzger, Michael Lochhead, David Goldberg, Charles Greef, David Grainger
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Publication number: 20050100675Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: October 13, 2004Publication date: May 12, 2005Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven Metzger, Michael Lochhead
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Publication number: 20050048599Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.Type: ApplicationFiled: July 8, 2004Publication date: March 3, 2005Inventors: David Goldberg, David Howson, Steven Metzger, Daniel Buttry, Steven Saavedra
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Patent number: 6272775Abstract: An excavator dragline bucket is supported by a hoist line from a dragline power unit, and pivots about the connection of the hoist line to the bucket. The bucket is designed to dump toward the rear, and has a gate that is latched in position during the loading of the bucket, and which will be automatically unlatched as the bucket tilts rearwardly. The gate is connected through a double pivoting bellcrank that is operated by control links connected to the hoist member such that as the angle between the bucket and the hoist member changes, the control link loads the double pivoting lever and releases the latch. When the bucket has been dumped and is returned to its horizontal position, the tailgate first moves against the rear edges of the bucket, and subsequently the double pivoting lever permits the tailgate to slide along its plane to a latched position.Type: GrantFiled: August 30, 1999Date of Patent: August 14, 2001Assignees: Dakota Coal CompanyInventors: Don F. Schmidt, DuWayne A. Marthaller, Karl Lemmerman, Dean Bray, William Lengenfelder, R. Steven Metzger