Abstract: A glass-based article including a first surface and a second surface opposing the first surface defining a thickness (t) of about 3 millimeters or less (e.g., about 1 millimeter or less), and a stress profile, wherein all points of the stress profile between a thickness range from about 0·t up to 0.3·t and from greater than about 0.7·t to t, comprise a tangent with a slope having an absolute value greater than about 0.1 MPa/micrometer. In some embodiments, the glass-based article includes a non-zero metal oxide concentration that varies along at least a portion of the thickness (e.g., 0·t to about 0.3·t) and a maximum central tension of less than about 71.5/?(t) (MPa). In some embodiments, the concentration of metal oxide or alkali metal oxide decreases from the first surface to a point between the first surface and the second surface and increases from the point to the second surface. The concentration of the metal oxide may be about 0.05 mol % or greater or about 0.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Systems, methods, and devices of the various embodiments enable a full keyboard of characters, such as Latin-based characters, to fit on a small touchscreen display. In an embodiment, a keyboard may be displayed including a text entry area and six virtual buttons. As a user interacts with the displayed keyboard, event actions may be determined based on the current displayed keyboard, the user input action indications received, and the text entry area state. The determined event actions may include displaying further keyboards, generating characters, and/or outputting character strings, and the event actions may be executed to enable the user to control character entry on a touchscreen display.

Abstract: A heat pump including a fluid circuit and a control arrangement. The fluid circuit includes a first heat exchanger, a second heat exchanger, a third heat exchanger and a driver for driving fluid about the fluid circuit. The control arrangement has one or more modes of operation. The first heat exchanger is arranged to exchange heat between the fluid of the fluid circuit and further fluid. The control arrangement is configured to in at least one of the modes of operation control a flow control mechanism to control a flow rate of the further fluid of the first heat exchanger.