Patents by Inventor Steven Millward

Steven Millward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-L1 BINDING PEPTIDES
    Publication number: 20230174616
    Abstract: The disclosure provides synthetic peptides that selectively bind to the PD-L1 protein on the surface of cells expressing PD-L1. The PD-L1 binding peptide may comprises the amino acid sequence MX1X2X3X4DHX5LNKFX6IX7HX8X9X10X11X12X13 (SEQ ID NO: 177) or MXIF?XXIXXX?WXLXXA (SEQ ID NO: 1). Peptides of the disclosure may be functionalized using one or more diagnostic agents to aid in various detection modalities or with a cytotoxic agent to treat various disease states such as cancer. Also provided are compositions that include the PD-L1 binding peptides or functionalized PD-L1 binding peptides.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Terry TAKAHASHI, Richard W. ROBERTS, Golnaz KAMALINIA, Justin ONG, Brian GRINDEL, Brian ENGEL, Steven MILLWARD
  • MACROCYCLIC PEPTIDES FOR TARGETED INHIBITION OF AUTOPHAGY
    Publication number: 20220096594
    Abstract: Provided herein are cyclic peptide inhibitors of autophagy that bind to LC3. These cyclic peptides may be used to treat diseases or disorders associated with autophagy, such as, for example, cancer, diabetes, cardiovascular disease, and neurological disorders. These cyclic peptides may also be used to sensitize cancers to front-line chemotherapy, immunotherapy, and/or radiation therapy.
    Type: Application
    Filed: January 30, 2020
    Publication date: March 31, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Steven MILLWARD, Joshua GRAY
  • Capture agents and related compositions, methods and systems
    Patent number: 9188584
    Abstract: Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: November 17, 2015
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Heather Agnew, Rosemary Rohde, Steven Millward, Arundhati Nag, James R. Heath
  • Capture agents and related compositions, methods and systems
    Patent number: 8906830
    Abstract: The present disclosure relates to capture agents for the detection and/or separation of one or more targets in a sample. Described herein are multi-ligand capture agents comprising two or more ligands, and related compositions, methods and systems. In certain embodiments, the capture agents disclosed herein can be used for performing assays, including but not limited to assays for the detection and/or separation of targets.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: December 9, 2014
    Assignee: California Institute of Technology
    Inventors: Heather Agnew, Rosemary Rohde, Steven Millward, Arundhati Nag, James R. Heath
  • CAPTURE AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20110263515
    Abstract: Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems.
    Type: Application
    Filed: February 25, 2011
    Publication date: October 27, 2011
    Inventors: Heather Agnew, Rosemary Rohde, Steven Millward, Arundhati Nag, James R. Heath
  • CAPTURE AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20100009896
    Abstract: Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 14, 2010
    Inventors: Heather AGNEW, Rosemary Rohde, Steven Millward, Arundhati Nag, James R. Heath