Patents by Inventor Steven N. Chatfield

Steven N. Chatfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of recombinant proteins in attenuated bacteria
    Patent number: 5547664
    Abstract: The invention concerns a vaccine comprising an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein. The nirB promoter directs expression of the heterologous protein in a host it is wished to vaccinate.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: August 20, 1996
    Assignee: Burroughs Wellcome Co.
    Inventors: Ian G. Charles, Steven N. Chatfield, Neil F. Fairweather
  • Vaccines comprising attenuated salmonella having mutations in the ompr genes
    Patent number: 5527529
    Abstract: The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: June 18, 1996
    Assignees: The Wellcome Foundation Limited, The Royal Society, The Lister Institute of Preventive Medicine, The University Court of The University of Dundee
    Inventors: Gordan Dougan, Steven N. Chatfield, Christopher F. Higgins, Charles J. Dorman