Patents by Inventor Steven Neville Chatfield

Steven Neville Chatfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines containing salmonella bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
    Patent number: 5770214
    Abstract: An attenuated microorganism harbouring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can be genetically engineered so as to express antigens from other pathogens and thus form the basis of a range of multi-valent vaccines.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: Glaxo Wellcome, Inc.
    Inventors: Gordon Dougan, Steven Neville Chatfield, Carlos Estenio Hormaeche
  • Expression of recombinant proteins in attenuated bacteria
    Patent number: 5683700
    Abstract: The invention concerns a method of prophylactically treating a host against infection by a microorganism, which method comprises administering to the host an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein. The heterologous protein is expressed in the host and induces in the host an immune response against the microorganism.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Ian George Charles, Steven Neville Chatfield, Neil Fraser Fairweather