Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A compression device can treat edema with a plurality of shell structures, each having an inside pad. A ligature network is routed across the shell structures. A plurality of tensioners mounted on at least some of the plurality of shells can separately adjust tension in different portions of the ligature network to affect the balance of compression forces at spaced positions along the plurality of padded shells. At least some of the shell structures have an underpass sized to accommodate passage of a portion of the ligature network. The underpass is integral with a corresponding one of the plurality of shell structures. In one case the shells include an interconnected plurality of volar shells placed on one side of a body part and a dorsal shell on the opposite side.

Abstract: A compression device can treat edema with a number of curved shells, each having an internal pad. A ligature network employing tensioners is routed across the shells for compressing them. Tensioners on at least some of the shells can separately adjust tension in different portions of the ligature network. The ligature network is (a) releasably mounted on the shells, and (b) repositionable to allow spatial adjustment of compression forces produced by the compression device. By adjusting the routing of the ligature network across the shells, tailored compression forces are provided. With a body part embraced by the padded shells, tension is separately adjusted in different portions of the ligature network to provide different compression forces at spaced positions along the plurality of padded shells.

Abstract: A compression device can treat edema with a plurality of shell structures, each having an inside pad. A ligature network is routed across the shell structures. A plurality of tensioners mounted on at least some of the plurality of shells can separately adjust tension in different portions of the ligature network to affect the balance of compression forces at spaced positions along the plurality of padded shells. At least some of the shell structures have an underpass sized to accommodate passage of a portion of the ligature network. The underpass is integral with a corresponding one of the plurality of shell structures. In one case the shells include an interconnected plurality of volar shells placed on one side of a body part and a dorsal shell on the opposite side.

Abstract: A compression device can treat edema with a number of curved shells, each having an internal pad. A ligature network employing tensioners is routed across the shells for compressing them. Tensioners on at least some of the shells can separately adjust tension in different portions of the ligature network. The ligature network is (a) releasably mounted on the shells, and (b) repositionable to allow spatial adjustment of compression forces produced by the compression device. By adjusting the routing of the ligature network across the shells, tailored compression forces are provided. With a body part embraced by the padded shells, tension is separately adjusted in different portions of the ligature network to provide different compression forces at spaced positions along the plurality of padded shells.