Patents by Inventor Steven Okino

Steven Okino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANT CLASSIFICATION THROUGH HIGH-CONFIDENCE MUTATION DETECTION FROM FLUORESCENCE SIGNALS MEASURED WITH A MULTIPLE MUTATION ASSAY
    Publication number: 20240076751
    Abstract: A system and method for SARS-CoV-2 variant classification through mutation detection from qPCR fluorescence signals. The system receives fluorescence signals, wherein a first fluorescence signal indicates quantitative presence of a first genomic region as a control for SARS-CoV-2, and a second fluorescence signal indicates quantitative presence of a second genomic region of a first mutation present in a subset of variants of SARS-CoV-2. The system measures a first Cq for the first fluorescence signal and a second Cq for the second fluorescence signal as the signals cross a threshold RFU. The system calculates a delta Cq as a difference between the two. Further, the system identifies a first peak RFU for the first fluorescence signal and a second peak RFU for the second fluorescence signal, and calculates a RFU ratio of the two. The system detects presence of the first mutation based on the delta Cq and/or the RFU ratio.
    Type: Application
    Filed: August 16, 2023
    Publication date: March 7, 2024
    Inventor: Steven Okino
  • PRE-AMPLIFICATION ASSAY
    Publication number: 20210381031
    Abstract: Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 9, 2021
    Inventors: Yanhong KONG, Steven OKINO
  • Kits comprising nucleic acid templates and primers for use in pre-amplification assays
    Patent number: 11124826
    Abstract: Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: September 21, 2021
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven Okino
  • Detection of RNA-interacting regions in DNA
    Patent number: 10760126
    Abstract: The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA.
    Type: Grant
    Filed: February 13, 2016
    Date of Patent: September 1, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Steven Okino
  • PRE-AMPLIFICATION ASSAY
    Publication number: 20190078135
    Abstract: Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
    Type: Application
    Filed: August 22, 2018
    Publication date: March 14, 2019
    Inventors: Yanhong KONG, Steven OKINO
  • Pre-amplification assay
    Patent number: 10077469
    Abstract: Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: September 18, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yanhong Kong, Steven Okino
  • SIZE SELECTION OF DNA FOR CHROMATIN ANALYSIS
    Publication number: 20170218444
    Abstract: Methods for analyzing chromosomal DNA, including chromatin, are provided.
    Type: Application
    Filed: February 8, 2017
    Publication date: August 3, 2017
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven OKINO, Yan WANG
  • DETECTION OF RNA-INTERACTING REGIONS IN DNA
    Publication number: 20160186258
    Abstract: The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA.
    Type: Application
    Filed: February 13, 2016
    Publication date: June 30, 2016
    Applicant: BIO-RAD LABORATORIES, INC.
    Inventor: Steven OKINO
  • Detection of RNA-interacting regions in DNA
    Patent number: 9273347
    Abstract: The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: March 1, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Steven Okino
  • PRE-AMPLIFICATION ASSAY
    Publication number: 20150315629
    Abstract: Provided herein are methods and compositions to determine the efficacy of a nucleic acid pre-amplification reaction.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 5, 2015
    Inventors: Yanhong Kong, Steven Okino
  • DETECTION OF RNA-INTERACTING REGIONS IN DNA
    Publication number: 20120082991
    Abstract: The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA.
    Type: Application
    Filed: September 9, 2011
    Publication date: April 5, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Steven Okino
  • SIZE SELECTION OF DNA FOR CHROMATIN ANALYSIS
    Publication number: 20120070829
    Abstract: Methods for analyzing chromosomal DNA, including chromatin, are provided.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 22, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Steven Okino, Yan Wang
  • DETECTION OF CHROMATIN STRUCTURE
    Publication number: 20120064517
    Abstract: The present invention provides methods of determining the accessibility of genomic DNA to a DNA modifying agent.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 15, 2012
    Applicant: Bio-Rad Laboratories, Inc.
    Inventor: Steven Okino