Patents by Inventor Steven P. Brundidge

Steven P. Brundidge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleoside process
    Patent number: 4879377
    Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: November 7, 1989
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chou Hong-Tann
  • Process for preparing cephalosporin intermediates
    Patent number: 4868294
    Abstract: Processes for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl, and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for intermediates in the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: September 19, 1989
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Paul R. Brodfuehrer, Chet Sapino, Jr., Kun M. Shih, Donald G. Walker
  • Cephalosporin intermediates
    Patent number: 4714760
    Abstract: Stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for, and intermediates in, the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: December 22, 1987
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Paul R. Brodfuehrer, Chet Sapino, Jr., Kun M. Shih, Donald G. Walker
  • Nucleoside process
    Patent number: 4625020
    Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
    Type: Grant
    Filed: November 18, 1983
    Date of Patent: November 25, 1986
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chon-Hong Tann
  • Process for the preparation of 7-aminocephalosporanic acids
    Patent number: 3932392
    Abstract: 7-Aminocephalosporanic acid (7-ACA) and 7-amino-3-methyl-3-cephem-4-carboxylic acid (7-ADCA) are valuable intermediates in the preparation of semi-synthetic cephalosporins. These compounds are commonly prepared by cleaving the amide bond of compounds having the formula ##SPC1##In which R.sup.6 is H or ##EQU1## R is the side chain of a known penicillin, especially phenoxymethyl or benzyl, and the amino and carboxyl functions are blocked; byA. halogenating the blocked compounds Ia or IIa to produce an imino-halide;B. forming an imino-ether from the imino-halide by treatment with an alcohol; andC. mixing said imino-ether with water or an alcohol to produce 7-aminocephalosporanic acid or 7-amino-3-methyl-3-cephem-4-carboxylic acid.The invention claimed is the use of dicyclohexylamine or diisopropylamine instead of a tertiary amine acid scavenger in step A.
    Type: Grant
    Filed: January 14, 1974
    Date of Patent: January 13, 1976
    Assignee: Bristol-Myers Company
    Inventors: David A. Johnson, Steven P. Brundidge, Albert L. Vulcano, Chester Sapino, Jr., James Mahan, Joseph H. Grossman