Patents by Inventor Steven P. Miller

Steven P. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10287595
    Abstract: Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: May 14, 2019
    Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.
    Inventors: W. Michael Ainley, Steven R. Webb, Jayakumar P. Samuel, Dmitry Y. Guschin, Jeffrey C. Miller, Lei Zhang
  • Publication number: 20170233382
    Abstract: This invention provides processes for the preparation of verubecestat (Compound of Formula (I)), a potent inhibitor of BACE-1 and BACE-2. In addition, the invention provides certain synthetic intermediates which are useful, among other things, for the preparation of the Compound of Formula (I).
    Type: Application
    Filed: August 10, 2015
    Publication date: August 17, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Steven P. Miller, Carmela Molinaro, David Thaisrivongs, Feng Xu, Richard Desmond, Hongming Li, Qinghao Chen, Andrew W. Stamford, Zhiguo Jake Song, Lushi Tan
  • Patent number: 9604985
    Abstract: A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R4—SO2W (II-Su) in the presence of tertiary amine base, wherein PG1 and PG2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R2, R3, R4, R5, R6, R7, R8, and R9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as ?-lactamase inhibitors.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: March 28, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Steven P. Miller, John Limanto, Yong-Li Zhong, Nobuyoshi Yasuda, Zhijian Liu
  • Publication number: 20160122350
    Abstract: A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R4—SO2W (II-Su) in the presence of tertiary amine base, wherein PG1 and PG2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R2, R3, R4, R5, R6, R7, R8, and R9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as ?-lactamase inhibitors.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 5, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Steven P. Miller, John Limanto, Yong-Li Zhong, Nobuyoshi Yasuda, Zhijian Liu
  • Patent number: 8680294
    Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: March 25, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John Traverse, William M. Leong, Steven P. Miller, Jennifer Albaneze-Walker, Thomas J. Hunter, Lijun Wang, Hongbiao Liao, Ashok Arasappan, Scott T. Trzaska, Randi M. Smith, Azzeddine Lekhal, Stephane L. Bogen, Jianshe Kong, Frank Bennett, F. George Njoroge, Marc Poirier, Shen-Chun Kuo, Yonggang Chen, Kenneth S. Matthews, Patrice Demonchaux, Amadeo Ferreira
  • Patent number: 8430938
    Abstract: According to typical inventive practice, an algorithm controls a reformer in order to produce a pure hydrogen stream for a hydrogen-using device. The inventive algorithmic feedback control maintains the permeate hydrogen stream at a permeate pressure setpoint. Pressure measurements are performed of the permeate hydrogen stream. Control data (e.g., including a “lookup” table) establishes at least three output levels (scaled from zero output to maximum output) of the permeate hydrogen stream and, for each output level, five variable setpoints (air flow rate, hydrocarbon flow rate, and steam flow rate preceding the reformer reaction; steam flow rate preceding the water-gas shift reaction; shaft rotational speed in the energy recovery device). The pressure signals and the control data are processed to determine the optimal output level and the associated variable setpoints. Control signals are sent to adjust the variables to the determined variable setpoints.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: April 30, 2013
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Steven P. Miller
  • Publication number: 20120178942
    Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
    Type: Application
    Filed: July 27, 2010
    Publication date: July 12, 2012
    Inventors: John Traverse, William M. Leong, Steven P. Miller, Jennifer Albaneze-Walker, Thomas J. Hunter, Lijun Wang, Hongbiao Liao, Ashok Arasappan, Scott T. Trzaska, Randi M. Smith, Azzeddine Lekhal, Stephane L. Bogen, Jianshe Kong, Frank Bennett, F. George Njoroge, Marc Poirier, Shen-Chun Kuo, Yonggang Chen, Kenneth S. Matthews, Patrice Demonchaux, Amadeo Ferreira
  • Patent number: 7640536
    Abstract: A method of verifying properties of a source program includes creating a directed multigraph from the source program. The directed multigraph is then minimized by identifying removable vertices in the multigraph. Based on the minimization of the directed multigraph, the source program is transformed by inlining variables in the source program to produce a transformed program. The transformed program is then model checked using a model checking tool in order to verify properties of the source program.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: December 29, 2009
    Assignee: Rockwell Collins, Inc.
    Inventors: Michael W. Whalen, Steven P. Miller
  • Patent number: 7535347
    Abstract: A system and process for optimizing vehicle service intervals for a plurality of vehicle service items begins with determination of a minimum service interval. The minimum service interval is set by the need to provide critical, though routine services such as engine oil changes and chassis lubrication. Multiple potential service intervals exist for at least one component, typically engine oil changes, based on different vehicle operating variables. Depending upon the character of vehicle use, one variable will control determination of the recommended interval for engine oil, which, after conversion to distance, is compared with the chassis lubrication to find the minimum service interval. Additional components/fluids are included for service based on operational variables selected to determine service intervals for these components.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: May 19, 2009
    Assignee: International Truck Intellectual Property Company, LLC
    Inventors: Gerald L. Larson, Kevin R. Carlstrom, Steven P. Miller
  • Publication number: 20080042820
    Abstract: A system and process for optimizing vehicle service intervals for a plurality of vehicle service items begins with determination of a minimum service interval. The minimum service interval is set by the need to provide critical, though routine services such as engine oil changes and chassis lubrication. Multiple potential service intervals exist for at least one component, typically engine oil changes, based on different vehicle operating variables. Depending upon the character of vehicle use, one variable will control determination of the recommended interval for engine oil, which, after conversion to distance, is compared with the chassis lubrication to find the minimum service interval. Additional components/fluids are included for service based on operational variables selected to determine service intervals for these components.
    Type: Application
    Filed: August 16, 2006
    Publication date: February 21, 2008
    Applicant: INTERNATIONAL TRUCK INTELLECTUAL PROPERTY COMPANY, LLC
    Inventors: Gerald L. Larson, Kevin R. Carlstrom, Steven P. Miller
  • Patent number: 7090605
    Abstract: An idler or tensioning assembly for an electronically controlled sanding/polishing machine is provided, the sanding/polishing machine utilizing a plurality of exchangeable polishing wheel assemblies of which the idler assembly is one. Each polishing wheel assembly interfaces with the sanding/polishing machine through a coolant manifold and a polishing wheel shaft receptor. The idler assembly is operative to provide releasable tension to a sanding/polishing belt that is situated around the idler and the associated sanding/polishing wheel. The idler assembly has a pivoting idler that is actuated by a hydraulic cylinder. The hydraulic cylinder utilizes coolant tapped from the coolant manifold of the idler assembly for actuation. Coolant is provided to the hydraulic cylinder in response to a valve signal. The idler assembly thus has a tensioned mode and an untensioned mode.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: August 15, 2006
    Assignee: DePuy Products, Inc.
    Inventors: Tracy A. Brookins, Daniel F. Knepper, David A. Smoker, Daniel S. O'Neil, Steven P. Miller
  • Patent number: 6840878
    Abstract: An idler or tensioning assembly for an electronically controlled sanding/polishing machine is provided, the sanding/polishing machine utilizing a plurality of exchangeable polishing wheel assemblies of which the idler assembly is one. Each polishing wheel assembly interfaces with the sanding/polishing machine through a coolant manifold and a polishing wheel shaft receptor. The idler assembly is operative to provide releasable tension to a sanding/polishing belt that is situated around the idler and the associated sanding/polishing wheel. The idler assembly has a pivoting idler that is actuated by a hydraulic cylinder. The hydraulic cylinder utilizes coolant tapped from the coolant manifold of the idler assembly for actuation. Coolant is provided to the hydraulic cylinder in response to a valve signal. The idler assembly thus has a tensioned mode and an untensioned mode.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: January 11, 2005
    Assignee: DePuy Products, Inc.
    Inventors: Tracy A. Brookins, Daniel F. Knepper, David A. Smoker, Daniel S. O'Neil, Steven P. Miller
  • Publication number: 20040121866
    Abstract: An idler or tensioning assembly for an electronically controlled sanding/polishing machine is provided, the sanding/polishing machine utilizing a plurality of exchangeable polishing wheel assemblies of which the idler assembly is one. Each polishing wheel assembly interfaces with the sanding/polishing machine through a coolant manifold and a polishing wheel shaft receptor. The idler assembly is operative to provide releasable tension to a sanding/polishing belt that is situated around the idler and the associated sanding/polishing wheel. The idler assembly has a pivoting idler that is actuated by a hydraulic cylinder. The hydraulic cylinder utilizes coolant tapped from the coolant manifold of the idler assembly for actuation. Coolant is provided to the hydraulic cylinder in response to a valve signal. The idler assembly thus has a tensioned mode and an untensioned mode.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 24, 2004
    Inventors: Tracy A. Brookins, Daniel F. Knepper, David A. Smoker, Daniel S. O'Neil, Steven P. Miller
  • Patent number: 6671594
    Abstract: The invention integrates a general purpose computer with a controller area network to effect an inspection regimen through the controller area network A convenient user interface, combining handheld instruments and convention displays and printers allows the driver to interact with the system. The computer provides storage for programs and processing power to implement test regimens in logical order relating to completion of the inspection.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: December 30, 2003
    Assignee: International Truck Intellectual Property Company, LLC
    Inventor: Steven P. Miller
  • Patent number: 6650977
    Abstract: The invention integrates a general purpose computer with a controller area network to effect an inspection regimen through the controller area network. A convenient user interface, combining handheld instruments and convention displays and printers allows the driver to interact with the system. The computer provides storage for programs and processing power to implement test regimens in logical order relating to completion of the inspection.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: November 18, 2003
    Assignee: International Truck Intellectual Property Company, LLC
    Inventor: Steven P. Miller
  • Publication number: 20030105566
    Abstract: The invention integrates a general purpose computer with a controller area network to effect an inspection regimen through the controller area network A convenient user interface, combining handheld instruments and convention displays and printers allows the driver to interact with the system. The computer provides storage for programs and processing power to implement test regimens in logical order relating to completion of the inspection.
    Type: Application
    Filed: January 15, 2003
    Publication date: June 5, 2003
    Inventor: Steven P. Miller
  • Publication number: 20030028296
    Abstract: The invention integrates a general purpose computer with a controller area network to effect an inspection regimen through the controller area network. A convenient user interface, combining handheld instruments and convention displays and printers allows the driver to interact with the system. The computer provides storage for programs and processing power to implement test regimens in logical order relating to completion of the inspection.
    Type: Application
    Filed: August 1, 2001
    Publication date: February 6, 2003
    Inventor: Steven P. Miller
  • Patent number: 6426813
    Abstract: A data transmission system for external use with a controller area network is installed on a motor vehicle undergoing high intensity electromagnetic interference susceptibility testing. The data transmission system includes a fiber optic cable extending from the immediate vicinity of the truck to a site relatively remote to the truck and out of the effective area of the artificially generated electromagnetic interference. An optical/electrical coupler in close proximity to the motor vehicle is connected to the vehicle controller area network to convert messages occurring on the network to optical signals. The connection is provided by an electrical cable constructed of a twisted pair of wires. The optical/electrical coupler is also connected to an end of the fiber optic cable in the vicinity of the truck. A remote data processing device is attached to the remote end of the fiber optic cable by an interface card installed in the remote data processing device.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: July 30, 2002
    Assignees: International Truck International Property Company, L.L.C., CyberMetrix, Inc.
    Inventors: Eric T. Swenson, Steven P. Miller, Bruce E. Thomason, Henry G. Gilbert
  • Patent number: 6173809
    Abstract: A safety stanchion for supporting a safety cable includes a tapered tubular post having a lower end for attachment to a support base at an oblique angle and an upper end for supporting the safety cable. The post preferably has a wall thickness of less than 0.125 inches, is frustoconically shaped and is made out of an energy absorbing, elastic-like steel such as A595 grade steel which in cooperation with the post's wall thickness and tapered, preferably frustoconical, shape is believed to render the post capable of in elastically deforming before it fails. A unique base or base assembly for mounting a stanchion upon a structural member such as an I beam, H beam or other structural beam having flange portions is also provided.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: January 16, 2001
    Assignee: MC Enterprises International, Inc.
    Inventors: Barry A. Cole, Steven P. Miller, Gerald W. Patrick
  • Patent number: 5475819
    Abstract: A distributed computing system using a data communications network may have a number of service providers for a given service or remote procedure call. A client on the network makes reference to a name service to obtain the network address of one of these service providers. The name service maintains for each client or group of clients a configuration profile of the service providers in order to resolve the issue of selecting one of the several service providers when a request is made. A single configuration profile is a priority-ordered search list that maps from a service identifier (e.g., remote procedure call interface specification) into service provider (e.g., remote procedure call server) names. A configuration profile may include names for individual service providers, and/or named groups of service providers, and/or other configuration profiles. Configuration profiles are stored in a manner that makes them accessible throughout the distributed system, e.g., in the name service.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: December 12, 1995
    Assignee: Digital Equipment Corporation
    Inventors: Steven P. Miller, Butler W. Lampson