Patents by Inventor Steven P. Schwendeman

Steven P. Schwendeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11439609
    Abstract: A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 13, 2022
    Assignee: The Regents of the University of Michigan
    Inventors: Gergely Lautner, Steven P. Schwendeman, Mark E. Meyerhoff
  • Publication number: 20220257769
    Abstract: The present disclosure relates to a porous self-healing polymer matrix for encapsulation of active macromolecules and a method of manufacturing said porous self-healing polymer matrix for a drug delivery system for a macromolecule.
    Type: Application
    Filed: July 20, 2020
    Publication date: August 18, 2022
    Inventors: Steven P. Schwendeman, Jason Albert, Rae Sung Chang, George A. Garcia
  • Publication number: 20220111173
    Abstract: Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 14, 2022
    Inventors: Gergely Lautner, Blake Stringer, Elizabeth J. Brisbois, Mark E. Meyerhoff, Steven P. Schwendeman
  • Publication number: 20210128484
    Abstract: The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 ?g/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeable shell surrounding the core. Methods of making and using the microspheres are also provided.
    Type: Application
    Filed: November 2, 2020
    Publication date: May 6, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Jie Tang
  • Publication number: 20210052732
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 25, 2021
    Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 10758619
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: September 1, 2020
    Assignees: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Publication number: 20200022916
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Application
    Filed: August 5, 2019
    Publication date: January 23, 2020
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Publication number: 20190307710
    Abstract: A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
    Type: Application
    Filed: June 10, 2016
    Publication date: October 10, 2019
    Inventors: Gergely Lautner, Steven P. Schwendeman, Mark E. Meyerhoff
  • Patent number: 10369106
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: August 6, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Publication number: 20190183802
    Abstract: Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affmity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Steven P. Schwendeman, Kashappa-Goud Desai
  • Publication number: 20190151237
    Abstract: Implants for anti-VEGF therapy provide both stability and controlled release of bevacizumab and other structurally sensitive polypeptides while maintaining protein/peptide stability in the micronized powder; achieving near zero order and complete release (>80%). Cylindrical implants suitable for intravitreal injection.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 23, 2019
    Inventors: Steven P. Schwendeman, Rae Sung Chang
  • Patent number: 10220001
    Abstract: Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: March 5, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Kashappa-Goud Desai
  • Publication number: 20150164805
    Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.
    Type: Application
    Filed: November 10, 2014
    Publication date: June 18, 2015
    Inventors: Steven P. Schwendeman, Ronak B. Shah, Morgan B. Giles, Rae Sung Chang, Anna A. Schwendeman
  • Publication number: 20150125531
    Abstract: Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
    Type: Application
    Filed: January 6, 2015
    Publication date: May 7, 2015
    Inventors: Steven P. Schwendeman, Kashappa-Goud Desai
  • Publication number: 20140056949
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Application
    Filed: November 15, 2011
    Publication date: February 27, 2014
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE OHIO STATE UNIVERSITY
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Publication number: 20120288537
    Abstract: Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
    Type: Application
    Filed: January 13, 2011
    Publication date: November 15, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 8017155
    Abstract: A method for encapsulating a biomacromolecule in a pore-containing polymer comprising the steps of providing an encapsulating solution containing the biomacromolecule and the pore-containing polymer; contacting the biomacromolecule with the pore-containing polymer for a time sufficient for the biomacromolecule to enter the pores of the pore-containing polymer; and rearranging the polymer such that the surface pores of the polymer are closed thus encapsulating the biomacromolecule in the pore-containing polymer.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: September 13, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Steven P. Schwendeman, Samuel E. Reinhold, III, Jichao Kang
  • Publication number: 20080182909
    Abstract: Methods for reducing or inhibiting the irreversible inactivation of water-soluble biologically active agents in biodegradable polymeric delivery systems which are designed to release such agents over a prolonged period of time, such as PLGA delivery systems are provided. The method comprises preparing PLGA delivery systems whose microclimate, i.e. the pores where the active agent resides, uniformly or homogenously maintain a pH of between 3 and 9, preferably between 4 and 8, more preferably between 5 and 7.5 during biodegradation.
    Type: Application
    Filed: September 27, 2007
    Publication date: July 31, 2008
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Steven P. Schwendeman, Gaozhong Zhu, Hanne Bentz, Jeffrey A. Hubbell, Wenlei Jiang, Anna Shenderova, Jichao Kang
  • Publication number: 20080131478
    Abstract: A method for encapsulating a biomacromolecule in a pore-containing polymer comprising the steps of providing an encapsulating solution containing the biomacromolecule and the pore-containing polymer; contacting the biomacromolecule with the pore-containing polymer for a time sufficient for the biomacromolecule to enter the pores of the pore-containing polymer; and rearranging the polymer such that the surface pores of the polymer are closed thus encapsulating the biomacromolecule in the pore-containing polymer.
    Type: Application
    Filed: May 16, 2005
    Publication date: June 5, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Steven P. Schwendeman, Samuel E. Reinhold, Jichao Kang
  • Publication number: 20040142887
    Abstract: Methods for enhancing immunogenic response to an antigen, particularly a peptide antigen in a mammalian subject. The method comprises administering a biodegradable polymeric delivery system which comprises one or more antigens of interest and a biologically effective amount of one or more basic additives to the mammalian subject. In a highly preferred embodiment, the basic additive in MgCO3, and the biodegradable polymeric delivery system is a PLGA microparticle. The present invention also relates to the immunogenic compositions used in the present method.
    Type: Application
    Filed: July 10, 2003
    Publication date: July 22, 2004
    Inventors: Chengji Cui, Steven P. Schwendeman, Vernon Stevens