Patents by Inventor Steven Paget

Steven Paget has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL STING AGONISTS
    Publication number: 20220048936
    Abstract: The present invention provides compounds of Formula I?: wherein W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Application
    Filed: September 7, 2021
    Publication date: February 17, 2022
    Applicant: Venenum Biodesign, LLC
    Inventors: David J. DILLER, Axel METZGER, David E. KAELIN, JR., Steven PAGET, Chia-Yu HUANG, Brian F. MCGUINNESS, Audrey Julie HOSPITAL, William Ronald SOLVIBILE, JR.
  • Sting agonists
    Patent number: 11161864
    Abstract: The present invention provides compounds of Formula I?: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: November 2, 2021
    Assignee: VENENUM BIODESIGN, LLC
    Inventors: David J. Diller, Axel Metzger, David E. Kaelin, Jr., Steven Paget, Chia-Yu Huang, Brian F. Mcguinness, Audrey Julie Hospital, William Ronald Solvibile, Jr.
  • NOVEL STING AGONISTS
    Publication number: 20200131209
    Abstract: The present invention provides compounds of Formula I?: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
    Type: Application
    Filed: October 24, 2019
    Publication date: April 30, 2020
    Inventors: David J. Diller, Axel Metzger, David E. Kaelin, JR., Steven Paget, Chia-Yu Huang, Brian F. Mcguinness, Audrey Julie Hospital, William Ronald Solvibile, JR.
  • BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS
    Publication number: 20130331395
    Abstract: The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The compounds of the present invention are serotonin transport inhibitors and/or modulators of 5HT1A.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 12, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventors: Christopher Creighton, Tina Morgan Ross, Allen B. Reitz, Cheryl P. Kordik, Steven Paget, Gregor J. Macdonald
  • Bridged aryl piperazines derivatives useful for the treatment of CNS, GI-urinary and reproductive disorders
    Patent number: 8530475
    Abstract: The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The compounds of the present invention are serotonin transport inhibitors and/or modulators of 5HT1A.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: September 10, 2013
    Inventors: Christopher J. Creighton, Tina Morgan Ross, Allen B. Reitz, Cheryl P. Kordik, Steven Paget, Gregor J. MacDonald
  • METHODS FOR TREATING HEPATITIS C
    Publication number: 20110268698
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
    Type: Application
    Filed: June 13, 2011
    Publication date: November 3, 2011
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Gary M. KARP, Peter Seongwoo HWANG, James J. TAKASUGI, Hongyu REN, Richard Gerald WILDE, Anthony A. TURPOFF, Alexander AREFOLOV, Guangming CHEN, Jeffrey Allen CAMPBELL, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Methods for treating hepatitis C
    Patent number: 7973069
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: July 5, 2011
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Jin Zhu, Xiaoyan Zhang
  • METHODS FOR TREATING HEPATITIS C
    Publication number: 20100305100
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Application
    Filed: July 1, 2010
    Publication date: December 2, 2010
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Gary Mitchell Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • METHODS FOR TREATING HEPATITIS C
    Publication number: 20100292187
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Application
    Filed: June 14, 2010
    Publication date: November 18, 2010
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey A. Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Methods for treating hepatitis C
    Patent number: 7781478
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: August 24, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary M. Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony A. Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Jin Zhu, Xiaoyan Zhang
  • Methods for treating hepatitis C
    Patent number: 7772271
    Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: August 10, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Peter Seongwoo Hwang, James J. Takasugi, Hongyu Ren, Richard Gerald Wilde, Anthony Turpoff, Alexander Arefolov, Guangming Chen, Jeffrey Allen Campbell, Chunshi Li, Steven Paget, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS
    Publication number: 20080070919
    Abstract: The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The compounds of the present invention are serotonin transport inhibitors and/or modulators of 5HT1A.
    Type: Application
    Filed: May 18, 2007
    Publication date: March 20, 2008
    Inventors: Christopher Creighton, Tina Ross, Allen Reitz, Cheryl Kordik, Steven Paget, Gregor MacDonald
  • 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones
    Publication number: 20060052359
    Abstract: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Application
    Filed: March 21, 2005
    Publication date: March 9, 2006
    Inventors: Eugene Grant, Mark Macielag, Steven Paget, Michele Weidner-Wells, Xiaoqing Xu, Xiaodong Xu
  • 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones
    Publication number: 20050101588
    Abstract: The present invention relates to compounds having a structure according to Formula I wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
    Type: Application
    Filed: September 9, 2004
    Publication date: May 12, 2005
    Inventors: Eugene Grant, Mark Macielag, Xiaoqing Xu, Steven Paget, Michele Weidner-Wells
  • Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
    Publication number: 20030171366
    Abstract: Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: 1
    Type: Application
    Filed: January 10, 2002
    Publication date: September 11, 2003
    Inventors: Steven Paget, Dennis Hlasta
  • Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
    Patent number: 6413981
    Abstract: Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of the formulae II or III: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: July 2, 2002
    Assignee: Ortho-McNeil Pharamceutical, Inc.
    Inventors: Steven Paget, Dennis Hlasta